Publication:
Critical illness myopathy and trajectory of recovery in acute kidney injury requiring continuous renal replacement therapy: a prospective observational trial protocol

Simple item page
dc.contributor.authorJ Pedro Teixeira, J. Pedro
dc.contributor.authorGriffin, Benjamin R.
dc.contributor.authorPal, Chaitanya Anil
dc.contributor.authorGonzález Seguel, Felipe
dc.contributor.authorJenkins, Nathanial
dc.contributor.authorJones, Beth M.
dc.contributor.authorYoshida, Yuri
dc.contributor.authorGeorge, Naomi
dc.contributor.authorIsrael, Hayley Puffer
dc.contributor.authorGhazi, Lama
dc.contributor.authorNeyra, Javier A.
dc.contributor.authorMayer, Kirby P.
dc.date.accessioned2024-06-04T21:28:29Z
dc.date.available2024-06-04T21:28:29Z
dc.date.issued2023
dc.description.abstractIntroduction Acute kidney injury requiring renal replacement therapy (AKI- RRT) is common in the intensive care unit (ICU) and is associated with significant morbidity and mortality. Continuous RRT (CRRT) non- selectively removes large amounts of amino acids from plasma, lowering serum amino acid concentrations and potentially depleting total- body amino acid stores. Therefore, the morbidity and mortality associated with AKI- RRT may be partly mediated through accelerated skeletal muscle atrophy and resulting muscle weakness. However, the impact of AKI- RRT on skeletal muscle mass and function during and following critical illness remains unknown. We hypothesise that patients with AKI- RRT have higher degrees of acute muscle loss than patients without AKI- RRT and that AKI- RRT survivors are less likely to recover muscle mass and function when compared with other ICU survivors. Methods and analysis This protocol describes a prospective, multicentre, observational trial assessing skeletal muscle size, quality and function in ICU patients with AKI- RRT. We will perform musculoskeletal ultrasound to longitudinally evaluate rectus femoris size and quality at baseline (within 48 hours of CRRT initiation), day 3, day 7 or at ICU discharge, at hospital discharge, and 1–3 months postdischarge. Additional skeletal muscle and physical function tests will be performed at hospital discharge and postdischarge follow- up. We will analyse the effect of AKI- RRT by comparing the findings in enrolled subjects to historical controls of critically ill patients without AKI- RRT using multivariable modelling. Ethics and dissemination We anticipate our study will reveal that AKI- RRT is associated with greater degrees of muscle loss and dysfunction along with impaired postdischarge recovery of physical function. These findings could impact the in- hospital and postdischarge treatment plan for these patients to include focused attention on muscle strength and function. We intend to disseminate findings to participants, healthcare professionals, the public and other relevant groups via conference resentation and publication without any publication restrictions.
dc.description.versionVersión aceptada
dc.format.extent10 p.
dc.identifier.citationTeixeira JP, Griffin BR, Pal CA, et al. Critical illness myopathy and trajectory of recovery in acute kidney injury requiring continuous renal replacement therapy: a prospective observational trial protocol. BMJ Open 2023;13:e072448. doi:10.1136/ bmjopen-2023-072448
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2023-072448
dc.identifier.urihttps://hdl.handle.net/11447/9034
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectAcute renal failure
dc.subjectAdult intensive & critical care
dc.subjectDialysis
dc.subjectNeuromuscular disease
dc.subjectRehabilitation medicine
dc.titleCritical illness myopathy and trajectory of recovery in acute kidney injury requiring continuous renal replacement therapy: a prospective observational trial protocol
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceBMJ Open
dspace.entity.typePublication
relation.isAuthorOfPublication507eb05b-daec-4369-9b2c-ce63a17a6844
relation.isAuthorOfPublication.latestForDiscovery507eb05b-daec-4369-9b2c-ce63a17a6844

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
e072448.full.pdf
Size:
785.67 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services