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A Third Dose of SARS-CoV-2 mRNA Vaccine Improves Immune Response in Chronic Kidney Disease Patients

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dc.contributor.authorPoli Harlowe, María Cecilia
dc.contributor.authorVial Cox, María Cecilia
dc.contributor.authorRey, Emma
dc.contributor.authorGonzález, Natalia
dc.contributor.authorCortés, Lina
dc.contributor.authorHormazabal, Juan
dc.contributor.authorRamírez, Carolina
dc.contributor.authorDe la Cruz, Javiera
dc.contributor.authorUlloa, Camilo
dc.date.accessioned2024-05-07T15:10:02Z
dc.date.available2024-05-07T15:10:02Z
dc.date.issued2023
dc.description.abstractChronic kidney disease (CKD) patients have an increased risk of morbidity and mortality following SARS-CoV-2 infection. Vaccination in these patients is prioritized, and monitoring of the immune response is paramount to define further vaccination strategies. This prospective study included a cohort of 100 adult CKD patients: 48 with kidney transplant (KT) and 52 on hemodialysis without prior COVID-19. The patients were assessed for humoral and cellular immune responses after four months of an anti-SARS-CoV-2 primary two-dose vaccination scheme (CoronaVac or BNT162b2) and one month after a booster third dose of BNT162b2 vaccine. We identified poor cellular and humoral immune responses in the CKD patients after a primary vaccination scheme, and these responses were improved by a booster. Robust polyfunctional CD4+ T cell responses were observed in the KT patients after a booster, and this could be attributed to a higher proportion of the patients having been vaccinated with homologous BNT162b2 schemes. However, even after the booster, the KT patients exhibited lower neutralizing antibodies, attributable to specific immunosuppressive treatments. Four patients suffered severe COVID-19 despite three-dose vaccination, and all had low polyfunctional T-cell responses, underscoring the importance of this functional subset in viral protection. In conclusion, a booster dose of SARS-CoV-2 mRNA vaccine in CKD patients improves the impaired humoral and cellular immune responses observed after a primary vaccination scheme.
dc.description.versionPublicada
dc.identifier.citationPoli MC, Vial C, Rey-Jurado E, González N, Cortés LJ, Hormazabal J, Ramírez-Riffo C, de la Cruz J, Ulloa C. A Third Dose of SARS-CoV-2 mRNA Vaccine Improves Immune Response in Chronic Kidney Disease Patients. Vaccines (Basel). 2023 May 22;11(5):1012. doi: 10.3390/vaccines11051012
dc.identifier.doihttps://doi.org/10.3390/vaccines11051012
dc.identifier.urihttps://hdl.handle.net/11447/8718
dc.language.isoen
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectChronic kidney disease
dc.subjectHemodialysis
dc.subjectImmune responses
dc.subjectKidney transplant
dc.subjectVaccination
dc.titleA Third Dose of SARS-CoV-2 mRNA Vaccine Improves Immune Response in Chronic Kidney Disease Patients
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceVaccines
dspace.entity.typePublication
relation.isAuthorOfPublicationbf711dbf-cd6f-4a66-97fb-64c15f664de3
relation.isAuthorOfPublication4cc9451a-447d-42c8-8e68-8669895ed0a0
relation.isAuthorOfPublication.latestForDiscoverybf711dbf-cd6f-4a66-97fb-64c15f664de3

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