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Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker

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dc.contributor.authorMeza, Gabriela
dc.contributor.authorLópez, René
dc.contributor.authorVial Cox, María Cecilia
dc.contributor.authorCortes, Lina
dc.contributor.authorRetamal, Mauricio A.
dc.contributor.authorDelgado, Iris
dc.date.accessioned2024-01-10T18:37:22Z
dc.date.available2024-01-10T18:37:22Z
dc.date.issued2023
dc.description.abstractHantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory illness primarily associated with microvascular endothelial changes, particularly in the lungs. However, the role of the pulmonary epithelium in HCPS pathogenesis remains unclear. This study explores the potential of soluble Receptors for Advanced Glycation End-products (sRAGE) as a biomarker for assessing pulmonary epithelial damage in severe HCPS, challenging the prevailing view that endothelial dysfunction is the sole driver of this syndrome. We conducted a cross-sectional study on critically ill HCPS patients, categorizing them into mild HCPS, severe HCPS, and negative control groups. Plasma sRAGE levels were measured, revealing significant differences between the severe HCPS group and controls. Our findings suggest that sRAGE holds promise as an indicator of pulmonary epithelial injury in HCPS and may aid in tracking disease progression and guiding therapeutic strategies. This study brings clarity on the importance of investigating the pulmonary epithelium's role in HCPS pathogenesis, offering potential avenues for enhanced diagnostic precision and support in this critical public health concern.
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dc.identifier.citationMeza-Fuentes G, López R, Vial C, Cortes LJ, Retamal MA, Delgado I, Vial P. Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker. Viruses. 2023 Sep 26;15(10):1995. doi: 10.3390/v15101995
dc.identifier.doihttps://doi.org/10.3390/v15101995
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/8324
dc.language.isoen
dc.subjectHantavirus cardiopulmonary syndrome
dc.subjectAcute respiratory distress syndrome
dc.subjectsRAGE
dc.titleAssessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceViruses
dspace.entity.typePublication
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relation.isAuthorOfPublication01e4a6fa-e55f-47c5-a1b6-383d5fc6f474
relation.isAuthorOfPublication963fc4d8-b9ef-4df5-88be-cd7075c2955f
relation.isAuthorOfPublication.latestForDiscovery4cc9451a-447d-42c8-8e68-8669895ed0a0

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