Publication: Características clínicas y resultados de pacientes con fibrosis quística con enfermedad pulmonar avanzada: experiencia en 10 años del Instituto Nacional del Tórax
dc.contributor.author | Gutiérrez M., José | |
dc.contributor.author | Pinochet F., Víctor | |
dc.contributor.author | Irazoqui G., Paula | |
dc.contributor.author | Benavides G., Guacolda | |
dc.contributor.author | Andrade H., Christian | |
dc.contributor.author | Orellana, María | |
dc.contributor.author | Melo T., Joel | |
dc.date.accessioned | 2024-06-12T20:50:50Z | |
dc.date.available | 2024-06-12T20:50:50Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Advanced cystic fibrosis lung disease (ACFLD) is the leading cause of morbidity and mortality in patients with Cystic Fibrosis (CF). Objective: to describe clinical characteristics of patients with CF with ACFLD and mortality during follow-up. Method: Descriptive, retrospective study of patients with CF and ACFLD: FEV1 ≤ 40%, oxygen dependent, and/or referred to a lung transplant program. Clinical, microbiological, functional, genetic and mortality characteristics were collected. Results: Of 111 controlled patients, 39% met criteria for ACFLD. 52% were men and the mean age was 29,8 yearsold. The average BMI was 19.9 kg/m2, 72% had pancreatic insufficiency and 87% had a genetic study, being the DF508 mutation the most frequent (67%). The average age of diagnosis was 11.2 years (SD ± 13 years), being in 54,5% over the age of 4 years. 75% had chronic Pseudomonas infection. 68% were oxygen dependent and 18% on noninvasive mechanical ventilation. In the last year of follow-up 70% had 2 or more hospitalizations. Of 27 patients who have been referred for transplantation, 7 underwent lung transplantation, 3 died waiting on the transplant list, 9 had contraindications: 4 due to malnutrition and 5 to poor adherence and poor support network. 32% (n = 14) of the ACFLD patients died, 93% due to respiratory causes. Conclusion: 39% of the patients had ACFLD. The average age for CF diagnosis was 11.2 years (SD ± 13 years) Barriers to entering the transplant list are: malnutrition, poor adherence, and lack of a support network. This is a population with a high mortality. | |
dc.description.version | Versión Publicada | |
dc.identifier.citation | Gutiérrez M., José, Pinochet F., Víctor, Irazoqui G., Paula, Benavides G., Guacolda, Andrade H., Christian, Orellana F., María, & Melo T., Joel. (2022). Características clínicas y resultados de pacientes con fibrosis quística con enfermedad pulmonar avanzada. Experiencia en 10 años del Instituto Nacional del Tórax. Revista chilena de enfermedades respiratorias, 38(4), 226-233. https://dx.doi.org/10.4067/S0717-73482022000400226 | |
dc.identifier.doi | http://dx.doi.org/10.4067/S0717-73482022000400226 | |
dc.identifier.uri | https://hdl.handle.net/11447/9088 | |
dc.language.iso | es | |
dc.rights | Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/cl/ | |
dc.subject | Seres humanos | |
dc.subject | Fibrosis quística | |
dc.subject | Estudios retrospectivos | |
dc.subject | Estudios de seguimiento | |
dc.subject | Comorbilidades | |
dc.subject | Desnutrición | |
dc.subject | Infecciones por pseudomonas | |
dc.title | Características clínicas y resultados de pacientes con fibrosis quística con enfermedad pulmonar avanzada: experiencia en 10 años del Instituto Nacional del Tórax | |
dc.type | Article | |
dcterms.accessRights | Acceso abierto | |
dcterms.source | Revista chilena de enfermedades respiratorias | |
dspace.entity.type | Publication |
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