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Identifying transcranial magnetic stimulation induced EEG signatures of different neuronal elements in primary motor cortex

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dc.contributor.authorNi, Zhen
dc.contributor.authorPajevic, Sinisa
dc.contributor.authorChen, Li
dc.contributor.authorLeodori, Giorgio
dc.contributor.authorVial Undurraga, Felipe
dc.contributor.authorAvram, Alexandru V.
dc.contributor.authorZhang, Yong
dc.contributor.authorMc Gurrin, Patrick
dc.contributor.authorCohen, Leonardo G.
dc.contributor.authorBasser, Peter J.
dc.contributor.authorHallett, Mark
dc.date.accessioned2023-07-12T17:28:53Z
dc.date.available2023-07-12T17:28:53Z
dc.date.issued2022
dc.description.abstractObjective: To investigate the neuronal elements involved in the activation of corticospinal neurons in the primary motor cortex (M1). Methods: We studied 10 healthy subjects. Cortical evoked potentials with different components induced by monophasic transcranial magnetic stimulation (TMS) in anterior-posterior and posterior-anterior currents recorded with electroencephalography (EEG) were analyzed. Results: EEG signatures with P25 and N45 components recorded at the C3 electrode with posterior-anterior current were larger than those with anterior-posterior current, while the signatures with P180 and N280 components recorded at the FC1 electrode with anterior-posterior current were larger than those with posterior-anterior current. The source localization analysis revealed that the cortical evoked potential with anterior-posterior current distributed both in the M1 and premotor cortex while that with posterior-anterior current only located in the M1. Conclusions: We conclude that the activation of corticospinal pyramidal neurons in the M1 is affected by various neuronal elements including the local intracortical circuits in the M1 and inputs from premotor cortex with different sensitivities to TMS in opposite current directions. Significance: Our finding helped answer a longstanding question about how the corticospinal pathway from the M1 is functionally organized and activated.
dc.description.versionVersión publicada
dc.identifier.citationi Z, Pajevic S, Chen L, Leodori G, Vial F, Avram AV, Zhang Y, McGurrin P, Cohen LG, Basser PJ, Hallett M. Identifying transcranial magnetic stimulation induced EEG signatures of different neuronal elements in primary motor cortex. Clin Neurophysiol. 2022 Sep;141:42-52. doi: 10.1016/j.clinph.2022.06.012.
dc.identifier.doihttps://doi.org/10.1016/j.clinph.2022.06.012
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7719
dc.language.isoen
dc.subjectCortical evoked potential
dc.subjectElectroencephalography
dc.subjectLatency
dc.subjectPremotor cortex
dc.subjectPrimary motor cortex
dc.subjectTranscranial magnetic stimulation current direction
dc.titleIdentifying transcranial magnetic stimulation induced EEG signatures of different neuronal elements in primary motor cortex
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceClinical Neurophysiology
dspace.entity.typePublication
relation.isAuthorOfPublication179d13e5-e6ce-4f28-bcd3-69797750d322
relation.isAuthorOfPublication.latestForDiscovery179d13e5-e6ce-4f28-bcd3-69797750d322

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