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Arsenic Exposure During Pregnancy and Childhood: Factors Explaining Changes over a Decade

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dc.contributor.authorRubilar, Paola
dc.contributor.authorHirmas, Macarena
dc.contributor.authorApablaza, Mauricio
dc.contributor.authorAwad, Camila
dc.contributor.authorMolina, Xaviera
dc.contributor.authorMuñoz, María Pía
dc.contributor.authorDelgado, Iris
dc.contributor.authorZanetta-Colombo, Nicolás C.
dc.contributor.authorCastillo-Laborde, Carla
dc.contributor.authorMatute, María Isabel
dc.contributor.authorRetamal, Mauricio
dc.contributor.authorOlea, Andrea
dc.contributor.authorPino, Paulina
dc.contributor.authorGonzález, Claudia
dc.contributor.authorCarvajal, Cristóbal
dc.contributor.authorIglesias, Verónica
dc.date.accessioned2026-07-21T20:52:33Z
dc.date.available2026-07-21T20:52:33Z
dc.date.issued2025
dc.description.abstractArsenic chronic exposure, particularly in its inorganic form, represents a significant public health concern. This study was conducted in Arica, the northernmost city in the country, whose inhabitants have been exposed to inorganic arsenic both naturally through drinking water and anthropogenically due to a toxic waste disposal site. We explored changes in inorganic arsenic levels in a cohort of pregnant women and their children over a decade, identifying exposure trends and their determinants. We used data on arsenic exposure through maternal urine samples during pregnancy, collected by the Health Authority between 2013 and 2016 (measurement 1), and followed up with assessments of their children in 2023 (measurement 2). Temporal changes in inorganic arsenic concentration were analyzed using the Wilcoxon Signed-Rank test, and a mixed linear regression model was employed to determine which factors contributed to urinary inorganic arsenic levels. We did not observe significant differences in mean arsenic concentrations between the two-time points (p = 0.4026). The mixed linear regression model revealed that children consuming bottled water had 8.3% lower urinary inorganic arsenic concentrations than those drinking tap water (95% CI: −15.36 to −0.54%). Additionally, children from ethnic groups had 8.64% higher inorganic arsenic concentrations (95% CI: 0.49 to 17.5%), while those with caregivers with higher education showed a 13.67% reduction (95% CI: −25.06 to −0.56%). Despite mitigation efforts, these findings underscore the ongoing risk of inorganic arsenic exposure among vulnerable populations. They further emphasize the importance of addressing natural arsenic contamination in water and implementing targeted interventions to reduce disparities associated with socioeconomic and demographic factors.
dc.description.versionVersión publicada
dc.format.extent14 p.
dc.identifier.citationRubilar, P., Hirmas-Adauy, M., Apablaza, M., Awad, C., Molina, X., Muñoz, M. P., Delgado, I., Zanetta-Colombo, N. C., Castillo-Laborde, C., Matute, M. I., Retamal, M. A., Olea, A., Pino, P., González, C., Carvajal, C., & Iglesias, V. (2025). Arsenic Exposure During Pregnancy and Childhood: Factors Explaining Changes over a Decade. Toxics, 13(3), 215. https://doi.org/10.3390/toxics13030215
dc.identifier.doihttps://doi.org/10.3390/ toxics13030215
dc.identifier.urihttps://hdl.handle.net/11447/10887
dc.language.isoen
dc.subjectInorganic arsenic
dc.subjectPrenatal exposure
dc.subjectBiomarker
dc.subjectExposure in children
dc.subjectEnviron- mental justice
dc.subjectWater exposure
dc.titleArsenic Exposure During Pregnancy and Childhood: Factors Explaining Changes over a Decade
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceToxics
dspace.entity.typePublication

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