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Electrospun Polyvinyl Alcohol/Sodium Alginate Nanocomposite Dressings Loaded with ZnO and Bioglass: Characterization, Antibacterial Activity, and Cytocompatibility

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dc.contributor.authorOrtiz, Andrés
dc.contributor.authorSepúlveda, Francesca
dc.contributor.authorFlores, Siomara
dc.contributor.authorSaavedra, Marcela
dc.contributor.authorSáez, Suhelen
dc.contributor.authorJiménez, Thomas
dc.contributor.authorMurgas, Paola
dc.contributor.authorTroncoso, Scarlett
dc.contributor.authorSanhueza, Camila
dc.contributor.authorUlloa, María
dc.contributor.authorPorte, Lorena
dc.contributor.authorAhumada, Manuel
dc.contributor.authorCorrales, Teresa
dc.contributor.authorPalza, Humberto
dc.contributor.authorZapata, Paula
dc.date.accessioned2026-09-28T15:55:17Z
dc.date.available2026-09-28T15:55:17Z
dc.date.issued2025
dc.description.abstractChronic wounds pose a great challenge due to their slow healing and susceptibility to infections, hence the need for innovative alternatives to conventional antibiotics, as increasing bacterial resistance limits the efficacy of current treatments. This paper addresses the development of novel electrospun membranes based on polyvinyl alcohol (PVA) and sodium alginate, incorporating therapeutic ZnO and bioglass (54SiO2:40CaO:6P2O5) nanoparticles. While nanocomposites presented smaller fiber diameters than pure polymers, ternary nanocomposites displayed higher values, e.g., in porous areas, values were in the ca. 80-240 nm range and 0.06-0.60 μm2, respectively. The Young's modulus of the PVA/SA membrane, initially 15.9 ± 2.0 MPa, decreased by 65% with 10 wt.% ZnO NPs, whereas 10 wt.% BG NPs increased it by 100%. The membranes demonstrated efficacy against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) isolated from a human wound secretion, as well as two ATCC strains: Staphylococcus aureus and Staphylococcus epidermidis. A cell viability assay conducted with HaCaT cells demonstrated nearly complete survival following 72 h of membrane exposure. Their combined Gram-positive antibacterial activity and cytocompatibility support their potential application as biofunctional dressings for the management of chronic and hospital-acquired topical infections, while also contributing to the global effort to combat antibiotic resistance.
dc.description.versionVersión Publicada
dc.identifier.citationOrtiz, J. A., Sepúlveda, F. A., Flores, S., Saavedra, M., Sáez-Silva, S., Jiménez, T., Murgas, P., Troncoso, S., Sanhueza, C., Ulloa, M. T., Porte Torre, L., Ahumada, M., Corrales, T., Palza, H., & Zapata, P. A. (2025). Electrospun Polyvinyl Alcohol/Sodium Alginate Nanocomposite Dressings Loaded with ZnO and Bioglass: Characterization, Antibacterial Activity, and Cytocompatibility. Polymers, 17(16), 2185. https://doi.org/10.3390/polym17162185
dc.identifier.doihttps://doi.org/10.3390/polym17162185
dc.identifier.urihttps://hdl.handle.net/11447/11192
dc.language.isoen
dc.subjectZnO
dc.subjectAntibacterial activity
dc.subjectBioglass
dc.subjectCytotoxicity
dc.subjectPolyvinyl alcohol
dc.subjectSodium alginate
dc.subjectWound dressing
dc.titleElectrospun Polyvinyl Alcohol/Sodium Alginate Nanocomposite Dressings Loaded with ZnO and Bioglass: Characterization, Antibacterial Activity, and Cytocompatibility
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourcePolymers
dspace.entity.typePublication

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