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Multimorbidity in acute ischemic stroke and its impact on short-term mortality: A Chilean nationwide database analysis

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dc.contributor.authorGonzález, Francisca
dc.contributor.authorAllende, María
dc.contributor.authorNuñez, Marilaura
dc.contributor.authorDelgado, Iris
dc.contributor.authorJakszyn, Paula
dc.contributor.authorDelfino, Carlos
dc.contributor.authorAnderson, Craig
dc.contributor.authorMunoz Venturelli, Paula
dc.date.accessioned2026-08-12T17:39:53Z
dc.date.available2026-08-12T17:39:53Z
dc.date.issued2025
dc.description.abstractBackground: Multimorbidity predicts a worse prognosis for various diseases but its impact in people after an acute ischemic stroke (AIS) in developing societies is not well established. We aimed to characterize the pattern of multimorbidity and determine its association with in-hospital mortality after AIS in the nationwide Chilean database. Methods: A retrospective analysis of the Diagnosis-Related Groups database for hospitalized adult patients in Chile in 2019 was conducted. Association of multimorbidity, defined as the presence of ≥2 health conditions, in patients with AIS (ICD-10 code I63) on in-hospital mortality was determined in logistic regression models adjusted for confounding variables. Results: Of 1,048,575 recorded ICD-10 codes, there were 10,440 AIS episodes in whom 7,696 (73.7 %) patients had multimorbidity. Age, female sex, and low socioeconomic status were associated with a higher multimorbidity, and the combination of comorbidities differed across age groups. Cardiometabolic multimorbidity was associated with higher in-hospital mortality (odds ratio [OR] 1.39, 95 % confidence interval [CI] 1.16-1.66; p<0.001). Stage 5 chronic kidney disease combined with ischemic heart disease was the comorbidity with the highest risk of death (OR 4.20, 95 %CI 1.58-11.16; p = 0.004). Obesity, which exhibited a predominance in early to mid-life, had the highest association with mortality when combined with other conditions. Conclusions: Multimorbidity is common in patients with AIS and its components vary by age and sex. Cardiometabolic multimorbidity increases the likelihood of in-hospital mortality. Adopting a multimorbidity-focused approach to stroke care could improve outcomes.
dc.description.versionVersión Publicada
dc.identifier.citationGonzález F, Allende MI, Nuñez M, Delgado I, Jakszyn P, Delfino C, Anderson CS, Muñoz Venturelli P. Multimorbidity in acute ischemic stroke and its impact on short-term mortality: A Chilean nationwide database analysis. J Stroke Cerebrovasc Dis. 2025 May;34(5):108267. doi: 10.1016/j.jstrokecerebrovasdis.2025.108267
dc.identifier.doihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108267
dc.identifier.urihttps://hdl.handle.net/11447/11005
dc.language.isoen
dc.subjectChile
dc.subjectDiagnosis-related groups
dc.subjectHospital mortality
dc.subjectIschemic stroke
dc.subjectMultimorbidity
dc.titleMultimorbidity in acute ischemic stroke and its impact on short-term mortality: A Chilean nationwide database analysis
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
dspace.entity.typePublication
relation.isAuthorOfPublication963fc4d8-b9ef-4df5-88be-cd7075c2955f
relation.isAuthorOfPublication77bec604-0a16-4d85-aaee-734c326e253a
relation.isAuthorOfPublication.latestForDiscovery963fc4d8-b9ef-4df5-88be-cd7075c2955f

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