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Educational disparities in brain health and dementia across Latin America and the United States

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dc.contributor.authorGonzalez, Raul
dc.contributor.authorLegaz, Agustina
dc.contributor.authorMoguilner, Sebastián
dc.contributor.authorCruzat, Josephine
dc.contributor.authorHernández, Hernán
dc.contributor.authorBaez, Sandra
dc.contributor.authorCocchi, Rafael
dc.contributor.authorCoronel, Carlos
dc.contributor.authorMedel,Vicente
dc.contributor.authorTagliazuchi, Enzo
dc.contributor.authorMigeot, Joaquín
dc.contributor.authorOchoa, Carolina
dc.contributor.authorMaito, Marcelo
dc.contributor.authorReyes, Pablo
dc.contributor.authorSantamaria, Hernando
dc.contributor.authorGodoy, Maria
dc.contributor.authorJavande, Shireen
dc.contributor.authorGarcía, Adolfo
dc.contributor.authorMatallana, Diana
dc.contributor.authorAvila, José
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.contributor.authorBehrens, María
dc.contributor.authorCustodio, Nilton
dc.contributor.authorCardona, Juan
dc.contributor.authorBrusco, Ignacio
dc.contributor.authorBruno, Martín
dc.contributor.authorSosa, Ana
dc.contributor.authorPina, Stefanie
dc.contributor.authorTakada, Leonel
dc.contributor.authorFrança, Elisa
dc.contributor.authorValcour, Victor
dc.contributor.authorPossin, Katherine
dc.contributor.authorDe Oliveira, Maira
dc.contributor.authorLopera, Francisco
dc.contributor.authorLawlor, Brian
dc.contributor.authorHu, Kun
dc.contributor.authorMiller, Bruce
dc.contributor.authorYokoyama, Jennifer
dc.contributor.authorGonzalez, Cecilia
dc.contributor.authorIbañez, Agustin
dc.date.accessioned2025-01-29T14:46:10Z
dc.date.available2025-01-29T14:46:10Z
dc.date.issued2024
dc.description.abstractBackground: Education influences brain health and dementia. However, its impact across regions, specifically Latin America (LA) and the United States (US), is unknown. Methods: A total of 1412 participants comprising controls, patients with Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD) from LA and the US were included. We studied the association of education with brain volume and functional connectivity while controlling for imaging quality and variability, age, sex, total intracranial volume (TIV), and recording type. Results: Education influenced brain measures, explaining 24%-98% of the geographical differences. The educational disparities between LA and the US were associated with gray matter volume and connectivity variations, especially in LA and AD patients. Education emerged as a critical factor in classifying aging and dementia across regions. Discussion: The results underscore the impact of education on brain structure and function in LA, highlighting the importance of incorporating educational factors into diagnosing, care, and prevention, and emphasizing the need for global diversity in research. Highlights: Lower education was linked to reduced brain volume and connectivity in healthy controls (HCs), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). Latin American cohorts have lower educational levels compared to the those in the United States. Educational disparities majorly drive brain health differences between regions. Educational differences were significant in both conditions, but more in AD than FTLD. Education stands as a critical factor in classifying aging and dementia across regions.
dc.description.versionVersión Aceptada
dc.identifier.citationGonzalez-Gomez R, Legaz A, Moguilner S, Cruzat J, Hernández H, Baez S, Cocchi R, Coronel-Olivero C, Medel V, Tagliazuchi E, Migeot J, Ochoa-Rosales C, Maito MA, Reyes P, Santamaria Garcia H, Godoy ME, Javandel S, García AM, Matallana DL, Avila-Funes JA, Slachevsky A, Behrens MI, Custodio N, Cardona JF, Brusco IL, Bruno MA, Sosa Ortiz AL, Pina-Escudero SD, Takada LT, Resende EPF, Valcour V, Possin KL, Okada de Oliveira M, Lopera F, Lawlor B, Hu K, Miller B, Yokoyama JS, Gonzalez Campo C, Ibañez A. Educational disparities in brain health and dementia across Latin America and the United States. Alzheimers Dement. 2024 Sep;20(9):5912-5925. doi: 10.1002/alz.14085
dc.identifier.doihttps://doi.org/10.1002/alz.14085
dc.identifier.urihttps://hdl.handle.net/11447/9732
dc.language.isoen
dc.subjectLatin America
dc.subjectUnited States
dc.subjectDementia
dc.subjectEducational disparities
dc.subjectHealthy aging
dc.subjectMagnetic resonance imaging
dc.titleEducational disparities in brain health and dementia across Latin America and the United States
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceAlzheimer's & dementia : the journal of the Alzheimer's Association
dspace.entity.typePublication
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoverye25c3d3e-63b5-4e04-951a-12a4989aa772

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