PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

Martínez, Nicolás; Gómez, Felipe; Tapia, Ariel; Roa, Juan; Moreso, Fernanda; Liu, Yuwei; Jara, Claudia; Tapia, Cheril; Alfaro, Ivan; Costa, Mauro; Matus, Soledad

Publication:
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

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PKR-driven ISR signaling controls synaptic translation and structural plasticityinanage-dependentmanner.pdf (6.45 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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1

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https://doi.org/10.1016/j.nbd.2025.107113

URI

https://hdl.handle.net/11447/11074

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Abstract

The integrated stress response (ISR) modulates protein homeostasis in response to both intracellular and extracellular signals. The four kinases involved in the ISR all phosphorylate the same target, ...

Citation

Martínez NW, Gómez F, Tapia-Godoy A, Roa JF, Moreso-Contreras F, Liu Y, Jara C, Tapia-Rojas C, Alfaro I, Costa-Mattioli M, Matus S. PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner. Neurobiol Dis. 2025 Nov;216:107113. doi: 10.1016/j.nbd.2025.10711

Keywords

Neurons , PKR , PSD95 , Proteostasis , Synapsin , eIF2α

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