Connexin46 in the nucleus of cancer cells: a possible role as transcription modulator

Fernández, Ainoa; Orellana, Viviana; Llanquinao, Jesús; Nuñez, Gonzalo; Perez Moreno, Pablo; Contreras, Sebastián; Martin, Alberto; Mammano, Fabio; Alfaro, Ivan; Calderón, Juan; Stehberg, Jimmy; Sáez, Mauricio; Retamal, Mauricio A.

Publication:
Connexin46 in the nucleus of cancer cells: a possible role as transcription modulator

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Connexin46 in the nucleus of cancer cells a possible role as transcription modulator.pdf (4.85 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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https://doi.org/10.1186/s12964-025-02151-w

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https://hdl.handle.net/11447/11011

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Abstract

Background: Oncogenes drive cancer progression, but few are active exclusively in tumor cells. Connexins (Cxs), traditionally recognized as ion channel proteins, can localize to the nucleus and regula...

Citation

Fernández-Olivares A, Orellana VP, Llanquinao J, Nuñez G, Pérez-Moreno P, Contreras-Riquelme S, Martin AJ, Mammano F, Alfaro IE, Calderón JF, Stehberg J, Sáez MA, Retamal MA. Connexin46 in the nucleus of cancer cells: a possible role as transcription modulator. Cell Commun Signal. 2025 Mar 27;23(1):153. doi: 10.1186/s12964-025-02151-w

Keywords

Cancer , Connexin46 , IRES , Transcription factor

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