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Incidence and prevalence of major epilepsy-associated brain lesions

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dc.contributor.authorLópez; Javier
dc.contributor.authorSmuk, Victoria
dc.contributor.authorLeu, Costin
dc.contributor.authorNasr, Gaelle
dc.contributor.authorVegh, Deborah
dc.contributor.authorStefanski, Arthur
dc.contributor.authorPérez, Eduardo
dc.contributor.authorBusch, Robyn
dc.contributor.authorJehi, Lara
dc.contributor.authorNajm, Imad
dc.contributor.authorBlümcke, Ingmar
dc.contributor.authorLal, Dennis
dc.date.accessioned2023-03-31T16:10:05Z
dc.date.available2023-03-31T16:10:05Z
dc.date.issued2022
dc.description.abstractEpilepsy surgery is an effective treatment option for drug-resistant focal epilepsy patients with associated structural brain lesions. However, little epidemiological data are available regarding the number of patients with these lesions. We reviewed data regarding (1) the prevalence and incidence of epilepsy; (2) the proportion of epilepsy patients with focal epilepsy, drug-resistant epilepsy, and drug-resistant focal epilepsies; and (3) the number of epilepsy presurgical evaluations and surgical resections. We also assessed the relative proportion of brain lesions using post-surgical histopathological findings from 541 surgical patients from the Cleveland Clinic and 9,523 patients from a European multi-center cohort. Data were combined to generate surgical candidate incidence and prevalence estimates and the first lesion-specific estimates for hippocampal sclerosis (HS), low-grade epilepsy-associated brain tumors (LEAT), malformations of cortical development (MCD), glial scars, vascular malformations, and encephalitis. The most frequently diagnosed brain lesions were HS (incidence = 2.32 ± 0.26 in 100,000, prevalence = 19.40 ± 2.16 in 100,000) for adults and MCD (incidence = 1.15 ± 0.34 in 100,000, prevalence = 6.52 ± 1.89 in 100,000) for children. Our estimates can guide patient advocacy groups, clinicians, researchers, policymakers in education, development of health care strategy, resource allocation, and reimbursement schedules.
dc.description.versionVersión publicada
dc.identifier.citationLópez-Rivera JA, Smuk V, Leu C, Nasr G, Vegh D, Stefanski A, Pérez-Palma E, Busch R, Jehi L, Najm I, Blümcke I, Lal D. Incidence and prevalence of major epilepsy-associated brain lesions. Epilepsy Behav Rep. 2022 Feb 11;18:100527. doi: 10.1016/j.ebr.2022.100527
dc.identifier.doihttps://doi.org/10.1016/j.ebr.2022.100527
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7220
dc.language.isoen
dc.subjectEpilepsy
dc.subjectEpilepsy surgery
dc.subjectMalformation of cortical development
dc.subjectHippocampal sclerosis
dc.subjectLow-grade Epilepsy-associated tumor
dc.titleIncidence and prevalence of major epilepsy-associated brain lesions
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceEpilepsy & Behavior Reports
dspace.entity.typePublication

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