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An analytical review of contributory factors in intervertebral disc degeneration

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dc.contributor.authorKumar, Vishal
dc.contributor.authorNeradi, Deepak
dc.contributor.authorMaheshwari, Shivam
dc.contributor.authorQuinteros, Guisela
dc.contributor.authorYurac, Ratko
dc.date.accessioned2023-04-11T21:04:37Z
dc.date.available2023-04-11T21:04:37Z
dc.date.issued2022
dc.description.abstractObjective: To summarize current trends in the pathogenesis and management of disc degeneration and suggest areas where more researchwould be of benefit. Methods: The available literature relevant to Lumbar disc degeneration (LDD) was reviewed. PubMed, MEDLINE, OVID, EMBASE, Cochrane, and Google Scholar databases were used to review the literature. Institutional Review Board approval was not applicable for this study. Results: This article summarizes trends in the pathogenesis and factors associated with disc degeneration. Conclusions: The genetic contribution to lumbar disc degeneration is a newer concept, still being researched in different populations around the world. Investigators have demonstrated a familial predisposition in the etiology of lumbar disc degeneration. The effect sizes of most genetic variants are small and, thus, individual gene-environment studies must have very large sample sizes to provide compelling evidence of any interaction
dc.description.versionVersión aceptada
dc.identifier.citationVishal Kumar, Deepak Neradi and Shivam Maheshwari et al. AN ANALYTICAL REVIEW OF CONTRIBUTORY FACTORS IN INTERVERTEBRAL DISC DEGENERATION. Coluna/Columna. 2022. Vol. 21(2). DOI: 10.1590/s1808-185120222102253646
dc.identifier.doihttps://doi.org/10.1590/S1808-185120222102253646
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7307
dc.language.isoen
dc.subjectEpidemiology
dc.subjectGenetics
dc.subjectAging
dc.subjectEnvironment
dc.titleAn analytical review of contributory factors in intervertebral disc degeneration
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceMinimally Invasive Surgery
dspace.entity.typePublication

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