Methadone directly impairs central nervous system cells in vitro

De Gregorio, Cristian; Gallardo, Javiera; Berríos, Pablo; Handy, Álex; Santapau, Daniela; González, Antonia; Ezquer, Marcelo; Morales, Paola; Luarte, Alejandro; Corvalán, Daniela; Wyneken, Úrsula; Ezquer, Fernando

Publication:
Methadone directly impairs central nervous system cells in vitro

Files

Methadone directly impairs central.pdf (7.25 MB)

Date

2024

Type:

Article

Collections

Artículos Medicina y Ciencias de la Salud

Descargas totales

89

Vistas totales

5

Métricas

Gestores bibliográficos

Authors

De Gregorio, Cristian

Gallardo, Javiera

Berríos, Pablo

Handy, Álex

Santapau, Daniela

González, Antonia

Ezquer, Marcelo

Morales, Paola

Luarte, Alejandro

Corvalán, Daniela

item.page.doiurl

https://doi.org/10.1038/s41598-024-67860-7

URI

https://hdl.handle.net/11447/9629

item.page.accessRights

Acceso Abierto

Abstract

Methadone is a synthetic long-acting opioid that is increasingly used in the replacement therapy of opioid-addicted patients, including pregnant women. However, methadone therapy in this population po...

Citation

De Gregorio C, Gallardo J, Berríos-Cárcamo P, Handy Á, Santapau D, González-Madrid A, Ezquer M, Morales P, Luarte A, Corvalán D, Wyneken Ú, Ezquer F. Methadone directly impairs central nervous system cells in vitro. Sci Rep. 2024 Jul 23;14(1):16978. doi: 10.1038/s41598-024-67860-7

Keywords

Brain damage , Methadone , Neurodegeneration , Neuroinflammation , Opioid addiction , Opioid substitution therapy

Estadísticas de uso

1 0,8 0,5 0,3 0