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Annona cherimola Seed Extracts Trigger an Early Apoptosis Response and Selective Anticlonogenic Activity against the Human Gastric Carcinoma Cell Line SNU-1

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dc.contributor.authorMacuer, Johan
dc.contributor.authorGiovagnoli, Claudia
dc.contributor.authorBernal, Giuliano
dc.contributor.authorLobos-González, Lorena
dc.contributor.authorDe la Fuente, Erwin
dc.contributor.authorAraya, Michael
dc.contributor.authorIbáñez, Cristian
dc.date.accessioned2024-05-08T14:58:01Z
dc.date.available2024-05-08T14:58:01Z
dc.date.issued2023
dc.description.abstractThe aim of this study was to evaluate, for the first time, the antiproliferative, apoptotic and diminishing effects of the anchored growth-independent capacity of an ethanol macerate extract from the Annona cherimola seed (EMCHS) in the human gastric cancer cell line SNU-1. The cells treated with EMCHS (20 μg/mL) significantly reduced the capacity to form clones of the tumor cell. Moreover, 50 μg/mL of EMCHS extract induced apoptosis, as was shown by the Annexin-V assay. UHPLC-MS/MS analysis detected two acetogenins (Annonacinone and Annonacin) in the EMCHS, which could be largely responsible for its selective antiproliferative effect. The identification of fatty acids by GC-FID showed the presence of eight fatty acids, among which was, oleic acid, which has recognized activity as an adjuvant in antitumor treatments. Taken together, our results indicate that the EMCHS seems promising for use as a natural therapy against gastric cancer disease.
dc.description.versionPublicada
dc.identifier.citationMacuer-Guzmán J, Giovagnoli-Vicuña C, Bernal G, Lobos-González L, de la Fuente-Ortega E, Araya-Castillo M, Ibáñez C. Annona cherimola Seed Extracts Trigger an Early Apoptosis Response and Selective Anticlonogenic Activity against the Human Gastric Carcinoma Cell Line SNU-1. Molecules. 2023 Oct 2;28(19):6906. doi: 10.3390/molecules28196906
dc.identifier.doihttps://doi.org/10.3390/molecules28196906
dc.identifier.urihttps://hdl.handle.net/11447/8724
dc.language.isoen
dc.subjectBioactivity
dc.subjectCancerous cells
dc.subjectEthanolic extract
dc.subjectFruit waste
dc.titleAnnona cherimola Seed Extracts Trigger an Early Apoptosis Response and Selective Anticlonogenic Activity against the Human Gastric Carcinoma Cell Line SNU-1
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceMolecules
dspace.entity.typePublication

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