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The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Mode

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dc.contributor.authorCuadra, Barbara
dc.contributor.authorSilva, Veronica
dc.contributor.authorHuang, Ya-Lin
dc.contributor.authorDiaz, Yael
dc.contributor.authorRivas, Claudio
dc.contributor.authorMolina, Cristobal
dc.contributor.authorSimon, Valeska
dc.contributor.authorBono, Maria
dc.contributor.authorMorales, Bernardo
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorSilva, Sebastian
dc.contributor.authorAcuña, Rodrigo
dc.contributor.authorEzquer, Fernando
dc.contributor.authorEzquer, Marcelo
dc.date.accessioned2025-01-13T15:33:41Z
dc.date.available2025-01-13T15:33:41Z
dc.date.issued2024
dc.description.abstractAcute-on-chronic liver failure (ACLF) is a syndrome marked by sudden liver function decline and multiorgan failure, predominantly acute kidney injury (AKY), in patients with chronic liver disease. Unregulated inflammation is a hallmark of ACLF; however, the key drivers of ACLF are not fully understood. This study explores the therapeutic properties of human mesenchymal stem cell (MSC) secretome, particularly focusing on its enhanced anti-inflammatory and pro-regenerative properties after the in vitro preconditioning of the cells. We evaluated the efficacy of the systemic administration of MSC secretome in preventing liver failure and AKI in a rat ACLF model where chronic liver disease was induced using by the administration of porcine serum, followed by D-galN/LPS administration to induce acute failure. After ACLF induction, animals were treated with saline (ACLF group) or MSC-derived secretome (ACLF-secretome group). The study revealed that MSC-secretome administration strongly reduced liver histological damage in the ACLF group, which was correlated with higher hepatocyte proliferation, increased hepatic and systemic anti-inflammatory molecule levels, and reduced neutrophil and macrophage infiltration. Additionally, renal examination revealed that MSC-secretome treatment mitigated tubular injuries, reduced apoptosis, and downregulated injury markers. These improvements were linked to increased survival rates in the ACLF-secretome group, endorsing MSC secretomes as a promising therapy for multiorgan failure in ACLF.
dc.description.versionVersión Publicada
dc.identifier.citationCuadra B, Silva V, Huang YL, Diaz Y, Rivas C, Molina C, Simon V, Bono MR, Morales B, Rosemblatt M, Silva S, Acuña R, Ezquer F, Ezquer M. The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model. Int J Mol Sci. 2024 Feb 8;25(4):2073. doi: 10.3390/ijms25042073
dc.identifier.doihttps://doi.org/10.3390/ijms25042073
dc.identifier.urihttps://hdl.handle.net/11447/9627
dc.language.isoen
dc.subjectAcute-on-chronic liver failure
dc.subjectIn vitro preconditioning
dc.subjectMesenchymal stem cells
dc.subjectMultiorgan failure
dc.subjectSecretome
dc.titleThe Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Mode
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceInternational journal of molecular sciences
dspace.entity.typePublication
relation.isAuthorOfPublicationc74766c7-dad8-4d11-b35d-01da0664f3da
relation.isAuthorOfPublication9cd4a8e6-6ba1-4344-80a2-45c260864d4c
relation.isAuthorOfPublication.latestForDiscoveryc74766c7-dad8-4d11-b35d-01da0664f3da

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