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LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells

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dc.contributor.authorPerez Moreno, Pablo
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorBizama, Carolina
dc.contributor.authorVergara, Luis
dc.contributor.authorTapia, Julio
dc.contributor.authorBrebi, Priscilla
dc.contributor.authorGarcía, Patricia
dc.contributor.authorRoa, Juan
dc.date.accessioned2024-12-17T17:10:24Z
dc.date.available2024-12-17T17:10:24Z
dc.date.issued2024
dc.description.sponsorshipLong non-coding RNAs (lncRNAs) are nucleotide sequences that participate in different biological processes and are associated with different pathologies, including cancer. Long intergenic non-protein-coding RNA 662 (LINC00662) has been reported to be involved in different cancers, including colorectal, prostate, and breast cancer. However, its role in gallbladder cancer has not yet been described. In this article, we hypothesize that LINC00662 has an important role in the acquisition of aggressiveness traits such as a stem-like phenotype, invasion, and chemoresistance in gallbladder cancer. Here, we show that LINC00662 is associated with larger tumor size and lymph node metastasis in patients with gallbladder cancer. Furthermore, we show that the overexpression of LINC00662 promotes an increase in CD133+/CD44+ cell populations and the expression of stemness-associated genes. LINC00662 promotes greater invasive capacity and the expression of genes associated with epithelial-mesenchymal transition. In addition, the expression of LINC00662 promotes resistance to cisplatin and 5-fluorouracil, associated with increased expression of chemoresistance-related ATP-binding cassette (ABC) transporters in gallbladder cancer (GBC) cell lines. Finally, we show that the mechanism by which LINC00662 exerts its function is through a decrease in microRNA 335-5p (miR-335-5p) and an increase in octamer-binding transcription factor 4 (OCT4) in GBC cells. Thus, our data allow us to propose LINC00662 as a biomarker of poor prognosis and a potential therapeutic target for patients with GBC.
dc.description.versionVersión Publicada
dc.identifier.citationPérez-Moreno P, Riquelme I, Bizama C, Vergara-Gómez L, Tapia JC, Brebi P, García P, Roa JC. LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells. Int J Mol Sci. 2024 Jun 19;25(12):6740. doi: 10.3390/ijms25126740.
dc.identifier.doihttps://doi.org/10.3390/ijms25126740
dc.identifier.urihttps://hdl.handle.net/11447/9496
dc.language.isoen
dc.subjectLINC00662
dc.subjectOCT4
dc.subjectgallbladder cancer
dc.subjectmiR-335-5p
dc.titleLINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceInternational journal of molecular sciences
dspace.entity.typePublication
relation.isAuthorOfPublicationd24481fe-ab73-4d4b-91bd-0eb3f120861a
relation.isAuthorOfPublication.latestForDiscoveryd24481fe-ab73-4d4b-91bd-0eb3f120861a

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