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Campylobacter spp. Prevalence in Santiago, Chile: A Study Based on Molecular Detection in Clinical Stool Samples from 2014 to 2019

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dc.contributor.authorPorte, Lorena
dc.contributor.authorPérez, Caricia
dc.contributor.authorBarbé, Mario
dc.contributor.authorVarela, Carmen
dc.contributor.authorVollrath, Valeska
dc.contributor.authorLegarraga, Paulette
dc.contributor.authorWeitzel, Thomas
dc.date.accessioned2024-05-02T20:50:20Z
dc.date.available2024-05-02T20:50:20Z
dc.date.issued2023
dc.description.abstractCampylobacter spp. is an emerging cause of infectious diarrhea worldwide. In South American countries such as Chile, its prevalence is underestimated due to inadequate detection methods. Gastrointestinal multiplex PCR panels (GMP) permit rapid and sensitive detection of bacterial pathogens and provide important epidemiological information. This study aimed to analyze Campylobacter epidemiology using the results of molecular methods and to compare molecular detection results to those of culture methods. We performed a retrospective, descriptive analysis of Campylobacter spp. detected in clinical stool samples between 2014-2019 by GMP and culture. Within 16,582 specimens examined by GMP, Campylobacter was the most prevalent enteropathogenic bacteria (8.5%), followed by Salmonella spp. (3.9%), Shigella spp./enteroinvasive Escherichia coli (EIEC) (1.9%), and Yersinia enterocolitica (0.8%). The highest Campylobacter prevalence occurred in 2014/2015. Campylobacteriosis affected more males (57.2%) and adults from 19-65 years (47.9%) and showed a bimodal seasonality with summer and winter peaks. In 11,251 routine stool cultures, Campylobacter spp. was detected in 4.6%, mostly C. jejuni (89.6%). Among 4533 samples tested by GMP and culture in parallel, GMP showed a superior sensitivity (99.1% versus 50%, respectively). The study suggests that Campylobacter spp. is the most frequent bacterial enteropathogen in Chile.
dc.description.versionPublicada
dc.identifier.citationPorte L, Pérez C, Barbé M, Varela C, Vollrath V, Legarraga P, Weitzel T. Campylobacter spp. Prevalence in Santiago, Chile: A Study Based on Molecular Detection in Clinical Stool Samples from 2014 to 2019. Pathogens. 2023 Mar 22;12(3):504. doi: 10.3390
dc.identifier.doihttps://doi.org/10.3390/pathogens12030504
dc.identifier.urihttps://hdl.handle.net/11447/8701
dc.language.isoen
dc.subjectPCR
dc.subjectSouth America
dc.subjectcampylobacteriosis
dc.subjectdiagnosis
dc.subjectepidemiology
dc.subjectgastrointestinal multiplex panel
dc.titleCampylobacter spp. Prevalence in Santiago, Chile: A Study Based on Molecular Detection in Clinical Stool Samples from 2014 to 2019
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourcePathogens
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryc641ef0c-51cb-4d25-8e9f-c8139bc6a4ad

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