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Trends in Inpatient Antibiotic Use Among Adults Hospitalized During the Coronavirus Disease 2019 Pandemic in Argentina, Brazil, and Chile, 2018-2021

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dc.contributor.authorPatel, Twisha
dc.contributor.authorMcGovern, Olivia
dc.contributor.authorMahon, Garrett
dc.contributor.authorOsuka, Hanako
dc.contributor.authorBoszczowski, Icaro
dc.contributor.authorMunita, Jose M.
dc.contributor.authorGarzon, Maria
dc.contributor.authorSalomao, Matias
dc.contributor.authorMarssola, Giovanna
dc.contributor.authorTavares, Bruno
dc.contributor.authorFrancisco, Debora
dc.contributor.authorGurgel, Alessandra
dc.contributor.authorArantes, Tiago
dc.contributor.authorBori, Andrea
dc.contributor.authorNogueira, Cassimiro
dc.contributor.authorPeters, Anne Sophie
dc.contributor.authorSpencer, Maria
dc.contributor.authorOrellana, Cristian
dc.contributor.authorBarbe, Mario
dc.contributor.authorLopez, Constanza
dc.contributor.authorStender, Stacie
dc.contributor.authorLessa, Fernanda
dc.date.accessioned2024-06-04T16:58:12Z
dc.date.available2024-06-04T16:58:12Z
dc.date.issued2023
dc.description.abstractBackground: High rates of antibiotic use (AU) among inpatients with coronavirus disease 2019 (COVID-19) despite low rates of bacterial coinfection and secondary infection have been reported. We evaluated the impact of the COVID-19 pandemic on AU in healthcare facilities (HCFs) in South America. Methods: We conducted an ecologic evaluation of AU in inpatient adult acute care wards in 2 HCFs each in Argentina, Brazil, and Chile. The AU rates for intravenous antibiotics were calculated as the defined daily dose per 1000 patient-days, using pharmacy dispensing records and hospitalization data from March 2018-February 2020 (prepandemic) and March 2020-February 2021 (pandemic). Differences in median AU were compared between the prepandemic and pandemic periods, using the Wilcoxon rank sum test to determine significance. Interrupted time series analysis was used to analyze changes in AU during the COVID-19 pandemic. Results: Compared with the prepandemic period, the median difference in AU rates for all antibiotics combined increased in 4 of 6 HCFs (percentage change, 6.7%-35.1%; P < .05). In the interrupted time series models, 5 of 6 HCFs had significant increases in use of all antibiotics combined immediately at the onset of the pandemic (immediate effect estimate range, 15.4-268), but only 1 of these 5 HCFs experienced a sustained increase over time (change in slope, +8.13; P < .01). The effect of the pandemic onset varied by antibiotic group and HCF. Conclusions: Substantial increases in AU were observed at the beginning of the COVID-19 pandemic, suggesting the need to maintain or strengthen antibiotic stewardship activities as part of pandemic or emergency HCF responses.
dc.description.versionPublicada
dc.identifier.citationPatel TS, McGovern OL, Mahon G, Osuka H, Boszczowski I, Munita JM, Garzon MI, Salomao MC, Marssola G, Tavares BM, Francisco DB, Gurgel APA, Arantes T, Bori A, Nogueira C, Peters A, Spencer M, Orellana C, Barbe M, Lopez C, Stender S, Lessa FC. Trends in Inpatient Antibiotic Use Among Adults Hospitalized During the Coronavirus Disease 2019 Pandemic in Argentina, Brazil, and Chile, 2018-2021. Clin Infect Dis. 2023 Jul 5;77(Suppl 1):S4-S11. doi: 10.1093/cid/ciad261
dc.identifier.doihttps://doi.org/10.1093/cid/ciad261
dc.identifier.urihttps://hdl.handle.net/11447/9018
dc.language.isoen
dc.subjectCOVID-19
dc.subjectSouth America
dc.subjectAntibiotic stewardship
dc.subjectAntibiotic use
dc.titleTrends in Inpatient Antibiotic Use Among Adults Hospitalized During the Coronavirus Disease 2019 Pandemic in Argentina, Brazil, and Chile, 2018-2021
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceClinical infectious diseases : an official publication of the Infectious Diseases Society of America
dspace.entity.typePublication
relation.isAuthorOfPublicationec52b0bf-d0bc-4844-9531-eca4a65f2b8e
relation.isAuthorOfPublication9aa6c0c0-19d6-4242-bf19-072f65ee8b0b
relation.isAuthorOfPublication.latestForDiscoveryec52b0bf-d0bc-4844-9531-eca4a65f2b8e

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