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Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

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dc.contributor.authorWalitt, Brian
dc.contributor.authorSingh, Komudi
dc.contributor.authorLaMunion, Samuel
dc.contributor.authorHallett , Mark
dc.contributor.authorJacobson, Steve
dc.contributor.authorChen, Kong
dc.contributor.authorEnose-Akahata, Yoshimi
dc.contributor.authorApps, Richard
dc.contributor.authorBarb, Jennifer
dc.contributor.authorBedard, Patrick
dc.contributor.authorBrychta, Robert
dc.contributor.authorBuckley, Ashura
dc.contributor.authorBurbelo, Peter
dc.contributor.authorCalco, Brice
dc.contributor.authorCathay, Brianna
dc.contributor.authorChen, Li
dc.contributor.authorChigurupati, Snigdha
dc.contributor.authorChen, Jinguo
dc.contributor.authorCheung, Foo
dc.contributor.authorChin, Lisa
dc.contributor.authorColeman, Benjamin
dc.contributor.authorCourville, Amber
dc.contributor.authorDeming, Madeleine
dc.contributor.authorDrinkard, Bart
dc.contributor.authorFeng, Li
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorGabel, Scott
dc.contributor.authorGavin, Angelique
dc.contributor.authorGoldstein, David
dc.contributor.authorHassanzadeh, Shahin
dc.contributor.authorHoran, Sean
dc.contributor.authorHorovitz, Silvina
dc.contributor.authorJohnson, Kory
dc.contributor.authorGovan, Anita
dc.contributor.authorKnutson, Kristine
dc.contributor.authorKreskow, Joy
dc.contributor.authorLevin, Mark
dc.contributor.authorLyons, Jonathan
dc.contributor.authorMadian, Nicholas
dc.contributor.authorVial Undurraga, Felipe
dc.date.accessioned2025-01-07T20:25:43Z
dc.date.available2025-01-07T20:25:43Z
dc.date.issued2024
dc.descriptionMalik, Nasir; Mammen, Andrew; McCulloch, John; McGurrin, Patrick; Milner, Joshua; Moaddel, Ruin; Mueller, Geoffrey; Mukherjee, Amrita; Muñoz, Sandra; Norato, Gina; Pak, Katherine; Pinal, Lago; Popa,Traian; N Sack, Michael; Safavi, Farinaz; Saligan, Leorey; Sellers, Brian; Sinclair, Stephen; Smith, Bryan; Snow, Joseph; Solin, Stacey; Stussman, Barbara; Trinchieri, Giorgio; Turner, Sara, Vetter, Stephenie; Vizioli, Carlotta, Williams, Ashley; Yang, Shanna; Center for Human Immunology, Autoimmunity, and Inflammation (CHI) Consortium; Avindra Nath.
dc.description.abstractPost-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.
dc.description.versionVersión Aceptada
dc.identifier.citationWalitt B, Singh K, LaMunion SR, Hallett M, Jacobson S, Chen K, Enose-Akahata Y, Apps R, Barb JJ, Bedard P, Brychta RJ, Buckley AW, Burbelo PD, Calco B, Cathay B, Chen L, Chigurupati S, Chen J, Cheung F, Chin LMK, Coleman BW, Courville AB, Deming MS, Drinkard B, Feng LR, Ferrucci L, Gabel SA, Gavin A, Goldstein DS, Hassanzadeh S, Horan SC, Horovitz SG, Johnson KR, Govan AJ, Knutson KM, Kreskow JD, Levin M, Lyons JJ, Madian N, Malik N, Mammen AL, McCulloch JA, McGurrin PM, Milner JD, Moaddel R, Mueller GA, Mukherjee A, Muñoz-Braceras S, Norato G, Pak K, Pinal-Fernandez I, Popa T, Reoma LB, Sack MN, Safavi F, Saligan LN, Sellers BA, Sinclair S, Smith B, Snow J, Solin S, Stussman BJ, Trinchieri G, Turner SA, Vetter CS, Vial F, Vizioli C, Williams A, Yang SB; Center for Human Immunology, Autoimmunity, and Inflammation (CHI) Consortium; Nath A. Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome. Nat Commun. 2024 Feb 21;15(1):907. doi: 10.1038/s41467-024-45107-3
dc.identifier.doihttps://doi.org/10.1038/s41467-024-45107-3
dc.identifier.urihttps://hdl.handle.net/11447/9576
dc.language.isoen
dc.subjectBiomarkers / metabolism
dc.subjectCommunicable Diseases / metabolism
dc.subjectLeukocytes
dc.subjectMononuclear / metabolism
dc.subjectFatigue Syndrome
dc.subjectChronic / metabolism
dc.subjectPhenotype
dc.titleDeep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceNature communications
dspace.entity.typePublication
relation.isAuthorOfPublication179d13e5-e6ce-4f28-bcd3-69797750d322
relation.isAuthorOfPublication.latestForDiscovery179d13e5-e6ce-4f28-bcd3-69797750d322

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