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ADAR-Mediated A>I(G) RNA Editing in the Genotoxic Drug Response of Breast Cancer

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dc.contributor.authorBernal, Yanara
dc.contributor.authorDurán, Eduardo
dc.contributor.authorSolar, Isidora
dc.contributor.authorSagredo, Eduardo
dc.contributor.authorArmisén, Ricardo
dc.date.accessioned2024-07-30T19:33:19Z
dc.date.available2024-07-30T19:33:19Z
dc.date.issued2024
dc.description.abstractEpitranscriptomics is a field that delves into post-transcriptional changes. Among these modifications, the conversion of adenosine to inosine, traduced as guanosine (A>I(G)), is one of the known RNA-editing mechanisms, catalyzed by ADARs. This type of RNA editing is the most common type of editing in mammals and contributes to biological diversity. Disruption in the A>I(G) RNA-editing balance has been linked to diseases, including several types of cancer. Drug resistance in patients with cancer represents a significant public health concern, contributing to increased mortality rates resulting from therapy non-responsiveness and disease progression, representing the greatest challenge for researchers in this field. The A>I(G) RNA editing is involved in several mechanisms over the immunotherapy and genotoxic drug response and drug resistance. This review investigates the relationship between ADAR1 and specific A>I(G) RNA-edited sites, focusing particularly on breast cancer, and the impact of these sites on DNA damage repair and the immune response over anti-cancer therapy. We address the underlying mechanisms, bioinformatics, and in vitro strategies for the identification and validation of A>I(G) RNA-edited sites. We gathered databases related to A>I(G) RNA editing and cancer and discussed the potential clinical and research implications of understanding A>I(G) RNA-editing patterns. Understanding the intricate role of ADAR1-mediated A>I(G) RNA editing in breast cancer holds significant promise for the development of personalized treatment approaches tailored to individual patients' A>I(G) RNA-editing profiles.
dc.description.versionVersión Publicada
dc.identifier.citationBernal YA, Durán E, Solar I, Sagredo EA, Armisén R. ADAR-Mediated A>I(G) RNA Editing in the Genotoxic Drug Response of Breast Cancer. Int J Mol Sci. 2024 Jul 6;25(13):7424. doi: 10.3390/ijms25137424.
dc.identifier.doihttps://doi.org/10.3390/ijms25137424
dc.identifier.urihttps://hdl.handle.net/11447/9214
dc.language.isoen
dc.subjectA>I(G)
dc.subjectADAR1
dc.subjectDNA damage repair
dc.subjectRNA editing
dc.subjectbreast cancer
dc.subjectDrug resistance
dc.subjectDrug response
dc.subjectImmune response
dc.subjectSplicing alteration
dc.titleADAR-Mediated A>I(G) RNA Editing in the Genotoxic Drug Response of Breast Cancer
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceInternational journal of molecular sciences
dspace.entity.typePublication

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