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Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

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dc.contributor.authorMcWhinney, Sean
dc.contributor.authorBrosch, Katharina
dc.contributor.authorCalhoun, Vince
dc.contributor.authorCrespo, Benedicto
dc.contributor.authorCrossley, Nicolas
dc.contributor.authorDannlowski, Udo
dc.contributor.authorDickie, Erin
dc.contributor.authorDietze, Lorielle
dc.contributor.authorDonohoe, Gary
dc.contributor.authorDu Plessis, Stefan
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorEmsley, Robin
dc.contributor.authorFurstova. Petra
dc.contributor.authorGlahn, David
dc.contributor.authorGonzalez, Alfonso
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorNenadić , Igor
dc.contributor.authorOpe, Nils
dc.contributor.authorPfarr, Julia
dc.contributor.authorRodrigue, Amanda
dc.contributor.authorStein, Frederike
dc.contributor.authorŠvance, Patrik
dc.contributor.authorTordesillas, Diana
dc.contributor.authorUndurraga, Juan
dc.contributor.authorVázquez, Javier
dc.contributor.authorVoineskos, Aristotle
dc.contributor.authorWalton, Esther
dc.contributor.authorWeickert, Thomas
dc.contributor.authorShannon, Cynthia
dc.contributor.authorThompson, Paul
dc.contributor.authorVan Erp, Theo
dc.contributor.authorTurner, Jessica
dc.contributor.authorHajek, Tomas
dc.date.accessioned2023-04-21T19:28:08Z
dc.date.available2023-04-21T19:28:08Z
dc.date.issued2022
dc.description.abstractSchizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.
dc.description.versionVersión publicada
dc.identifier.citationMcWhinney SR, Brosch K, Calhoun VD, Crespo-Facorro B, Crossley NA, Dannlowski U, Dickie E, Dietze LMF, Donohoe G, Du Plessis S, Ehrlich S, Emsley R, Furstova P, Glahn DC, Gonzalez-Valderrama A, Grotegerd D, Holleran L, Kircher TTJ, Knytl P, Kolenic M, Lencer R, Nenadić I, Opel N, Pfarr JK, Rodrigue AL, Rootes-Murdy K, Ross AJ, Sim K, Škoch A, Spaniel F, Stein F, Švancer P, Tordesillas-Gutiérrez D, Undurraga J, Vázquez-Bourgon J, Voineskos A, Walton E, Weickert TW, Weickert CS, Thompson PM, van Erp TGM, Turner JA, Hajek T. Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals. Mol Psychiatry. 2022 Sep;27(9):3731-3737. doi: 10.1038/s41380-022-01616-5
dc.identifier.doihttps://doi.org/10.1038/s41380-022-01616-5
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7364
dc.language.isoen
dc.subjectDepressive Disorder, Major
dc.subjectMagnetic Resonance Imaging / methods
dc.subjectSchizophrenia*
dc.subjectObesity
dc.subjectBrain
dc.titleObesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceMolecular Psychiatry
dspace.entity.typePublication

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