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Cryopreserved Total Skin Allografts From Living Donors for Complex Wound Management: A New Paradigm in Regenerative Wound Care

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dc.contributor.authorFonseca, Marcelo
dc.contributor.authorCañete, Aldo
dc.contributor.authorMandriaza, Luana
dc.contributor.authorGómez, Jennifer
dc.contributor.authorMasiá, Jaume
dc.contributor.authorMarcelain, Katherine
dc.contributor.authorIbaceta, Dino
dc.contributor.authorErazo, Cristian
dc.contributor.authorGámez, Brenda
dc.contributor.authorRius, Montserrat
dc.contributor.authorDisi, Florencia
dc.date.accessioned2026-08-05T20:39:24Z
dc.date.available2026-08-05T20:39:24Z
dc.date.issued2025
dc.description.abstractSkin allografts are essential in managing complex wounds, yet their availability is limited by low post-mortem donation rates. Skin harvested during body contouring surgeries offers a novel and sustainable source to expand tissue supply. We conducted a retrospective descriptive study at the Tarapacá Skin and Tissue Bank from January 2022 to December 2024. All donations from body contouring surgeries were processed as cryopreserved total skin allografts following national tissue banking stand- ards. Variables included donor demographics, harvested area, units produced, microbiological results, and discard rates. To describe clinical performance, we present our group's initial clinical series of treated patients. From 248 living donors (mean age 41.3 years), 81 293 cm2 of skin generated 2050 units. The discard rate was 27%, mainly due to a storage failure and isolated micro- bial contamination. Clinically, all patients achieved complete initial graft take, followed by gradual necrotic eschar formation at an average of 21 days. Eschar removal revealed vital tissue firmly adhered to the recipient bed, rich in fibroblasts and neovascu- lar structures. Subsequent management included either escharectomy with split-thickness autografting over the neodermis, or spontaneous eschar lysis and skin regeneration, with the graft functioning as a dermal regenerator. This model increases tissue availability while providing allografts with both coverage and dermal regenerative properties.
dc.description.versionVersión publicada
dc.format.extent14 p.
dc.identifier.citationM. Fonseca, A. Cañete, L. Mandriaza, et al., “ Cryopreserved Total Skin Allografts From Living Donors for Complex Wound Management: A New Paradigm in Regenerative Wound Care,” International Wound Journal 22, no. 9 (2025): e70759, https://doi.org/10.1111/iwj.70759
dc.identifier.doihttps://doi.org/10.1111/iwj.70759
dc.identifier.urihttps://hdl.handle.net/11447/10959
dc.language.isoen
dc.subjectSkin allograft
dc.subjectTissue banks
dc.subjectWound healing
dc.titleCryopreserved Total Skin Allografts From Living Donors for Complex Wound Management: A New Paradigm in Regenerative Wound Care
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceInternational Wound Journal
dspace.entity.typePublication

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