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A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement

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dc.contributor.authorAgrawal, Vinisha
dc.contributor.authorFarhan Ali, Mohammed
dc.contributor.authorYasin, Froher
dc.contributor.authorAshraf, Daniyal
dc.contributor.authorBrannigan, Jamie F. M.
dc.contributor.authorYurac, Ratko
dc.contributor.authorKumar, Vishal
dc.contributor.authorMurphy, Rory
dc.contributor.authorTessitore, Enrico
dc.contributor.authorMolliqaj, Granit
dc.contributor.authorDejaegher, Joost
dc.contributor.authorZamorano, Juan José
dc.contributor.authorWynne-Jones, Guy
dc.contributor.authorTripathi, Manjul
dc.contributor.authorAnderson, David B.
dc.contributor.authorArbatin, Jose Joefrey F.
dc.contributor.authorKato, So
dc.contributor.authorRomelean Jayapalan, Ronie
dc.contributor.authorDea, Nicolas
dc.contributor.authorHarrop, James S.
dc.contributor.authorWilson, Jefferson
dc.contributor.authorKwon, Brian K.
dc.contributor.authorMartin, Allan R.
dc.contributor.authorBednarik, Josef
dc.contributor.authorKotter, Mark R.
dc.contributor.authorDavies, Benjamin M.
dc.contributor.authorMowforth, Oliver D.
dc.contributor.authorNouri. Aria
dc.date.accessioned2026-08-10T21:05:50Z
dc.date.available2026-08-10T21:05:50Z
dc.date.issued2025
dc.description.abstractStudy Design: Systematic review. Objectives: The pre-symptomatic state of Degenerative Cervical Myelopathy (DCM), wherein degenerative changes and spinal cord compression are seen without clinical findings, is poorly understood and inconsistently categorised. Clear identification may elucidate the temporality of DCM development. Therefore, a systematic assessment was undertaken of current terminology for pre-DCM states, with the objective of standardising definitions and informing an AO Spine expert position statement. Methods: Medline and Embase were searched for all studies on asymptomatic spinal compression or clinical findings preceding DCM, returning 3585 studies. After screening, 96 studies were included in the final analysis. The terminology used for pre-DCM states and their definitions were extracted, along with their frequencies or speciality/country of author in the literature. Results: Multiple terms were used to represent pre-DCM stages, including “asymptomatic” (86 studies), “non-myelopathic” (26 studies), “without myelopathy” (15 studies), “pre-symptomatic” (9 studies) and “sub-clinical” (7 studies). “asymptomatic” was associated with the greatest inconsistency. Some defined this as patients with radiological signs of spinal degeneration with/without spinal cord compression but no clinical signs of myelopathy, whereas others used the term synonymously with healthy controls. This inconsistency is particularly challenging in clinical studies in which DCM patients are compared to those with pre- DCM states and/or healthy volunteers. Conclusion: There is substantial inconsistency in the terms used to describe pre-DCM states. There is no clear relationship between the terms used and the country or speciality of the main author. Standardised definitions for these disease states should be agreed and used in future studies.
dc.description.versionVersión publicada
dc.format.extent11 p.
dc.identifier.citationAgrawal V, Ali MF, Yasin F, et al. A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement. Global Spine Journal. 2025;15(7):3506-3516. doi:10.1177/21925682251339480
dc.identifier.doihttps://doi.org/10.1177/21925682251339480
dc.identifier.urihttps://hdl.handle.net/11447/10989
dc.language.isoen
dc.subjectCervical myelopathy
dc.subjectSpinal cord compression
dc.subjectOssification of the posterior longitudinal ligament
dc.subjectSpondylosis
dc.subjectDisc herniation
dc.subjectCervical stenosis
dc.subjectSpinal stenosis
dc.titleA Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceGlobal Spine Journal
dspace.entity.typePublication

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