Publication:
Temporal Trends of Intravenous Thrombolysis Utilization in Acute Ischemic Stroke in a Prospective Cohort From 1998 to 2019: Modeling Based on Joinpoint Regression

Simple item page
dc.contributor.authorOlavarría, Verónica
dc.contributor.authorHoffmeiste, Lorena
dc.contributor.authorVidal, Carolina
dc.contributor.authorBrunser, Alejandro
dc.contributor.authorHoppe, Arnold
dc.contributor.authorLavados, Pablo
dc.date.accessioned2023-07-07T16:45:13Z
dc.date.available2023-07-07T16:45:13Z
dc.date.issued2022
dc.description.abstractIntroduction: The frequency of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) is lower than it should be in several regions of the world. It is unclear what interventions can produce significant improvements in IVT utilization. We aimed to investigate the temporal trends in IVT in AIS and identify changes in time that could be associated with specific interventions. Methods: We included patients with AIS who were admitted from January 1998 to December 2019 in our institution. To analyze trends in utilization and time points in which they changed, we performed a Joinpoint regression analysis. Interventions were assigned to a specific category according to the Behavior Change Wheel framework intervention function criteria. Results: A total of 3,361 patients with AIS were admitted, among which 538 (16%) received IVT. There were 245 (45.5%) women, and the mean age and median National Institutes of Health Stroke Scale (NIHSS) scores were 68.5 (17.2) years and 8 (interquartile range, 4-15), respectively. Thrombolysis use significantly increased by an average annual 7.6% (95% CI, 5.1-10.2), with one Joinpoint in 2007. The annual percent changes were.45% from 1998 to 2007 and 9.57% from 2007 to 2019, concurring with the stroke code organization, the definition of door-to-needle times as an institutional performance measure quality indicator, and the extension of the therapeutic window. Conclusions: The IVT rates consistently increased due to a continuous process of protocol changes and multiple interventions. The implementation of a complex multidisciplinary intervention such as the stroke code, as well as the definition of a hospital quality control metric, were associated with a significant change in this trend.
dc.description.versionVersión Publicada
dc.identifier.citationOlavarría VV, Hoffmeister L, Vidal C, Brunser AM, Hoppe A, Lavados PM. Temporal Trends of Intravenous Thrombolysis Utilization in Acute Ischemic Stroke in a Prospective Cohort From 1998 to 2019: Modeling Based on Joinpoint Regression. Front Neurol. 2022 Apr 8;13:851498. doi: 10.3389/fneur.2022.851498
dc.identifier.doihttps://doi.org/10.3389/fneur.2022.851498
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7660
dc.language.isoen
dc.subjectIntravenous thrombolysis
dc.subjectJoinpoint regression
dc.subjectIschemic stroke
dc.subjectDoor-to-needle time
dc.subjectPerformance measures
dc.subjectPerformance measures
dc.subjectBehavioral change wheel
dc.subjectImplementation
dc.titleTemporal Trends of Intravenous Thrombolysis Utilization in Acute Ischemic Stroke in a Prospective Cohort From 1998 to 2019: Modeling Based on Joinpoint Regression
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceFrontiers in neurology
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Temporal Trends of Intravenous Thrombolysis Utilization in Acute Ischemic Stroke in a Prospective Cohort From 1998 to 2019.pdf
Size:
1.16 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services