Publication:
Neurocognitive correlates of semantic memory navigation in Parkinson's disease

Simple item page
dc.contributor.authorToro, Felipe
dc.contributor.authorMigeot, Joaquín
dc.contributor.authorMarchant, Nicolás
dc.contributor.authorOlivares, Daniela
dc.contributor.authorFerrante, Franco
dc.contributor.authorGonzález, Raúl
dc.contributor.authorGonzález, Cecilia
dc.contributor.authorFittipaldi, Sol
dc.contributor.authorRojas, Gonzalo
dc.contributor.authorMoguilner, Sebastian
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.contributor.authorChaná, Pedro
dc.contributor.authorIbáñez, Agustín
dc.contributor.authorChaigneau, Sergio
dc.contributor.authorGarcía, Adolfo
dc.date.accessioned2025-01-07T16:04:53Z
dc.date.available2025-01-07T16:04:53Z
dc.date.issued2024
dc.description.abstractCognitive studies on Parkinson's disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients' neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., 'sun') and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive status. PD and bvFTD patients showed reduced semantic variability, an anomaly which predicted semantic inhibition outcomes. Word-property patterns robustly classified PD (but not bvFTD) patients and correlated with disease-specific hypoconnectivity along the sensorimotor and salience networks. Fine-grained semantic assessments, then, can reveal distinct neurocognitive signatures of PD.
dc.description.versionVersión Publicada
dc.identifier.citationToro-Hernández FD, Migeot J, Marchant N, Olivares D, Ferrante F, González-Gómez R, González Campo C, Fittipaldi S, Rojas-Costa GM, Moguilner S, Slachevsky A, Chaná Cuevas P, Ibáñez A, Chaigneau S, García AM. Neurocognitive correlates of semantic memory navigation in Parkinson's disease. NPJ Parkinsons Dis. 2024 Jan 9;10(1):15. doi: 10.1038/s41531-024-00630-4. Erratum in: NPJ Parkinsons Dis. 2024 Jan 29;10(1):30. doi: 10.1038/s41531-024-00644-y
dc.identifier.doihttps://doi.org/10.1038/s41531-024-00630-4
dc.identifier.urihttps://hdl.handle.net/11447/9566
dc.language.isoen
dc.subjectParkinson's
dc.subjectNeurocognitive
dc.titleNeurocognitive correlates of semantic memory navigation in Parkinson's disease
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceNPJ Parkinson's disease
dspace.entity.typePublication
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoverye25c3d3e-63b5-4e04-951a-12a4989aa772

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Neurocognitive correlates of semantic memory navigation in Parkinson’s disease.pdf
Size:
2.26 MB
Format:
Adobe Portable Document Format
Description:
Texto Completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services