Publication:
Genetic and epigenetic landscape of early-onset oral squamous cell carcinoma: Insights of genomic underserved and underrepresented populations

Simple item page
dc.contributor.authorAdorno, Daniela
dc.contributor.authorMorales, Sebastián
dc.contributor.authorGischkow, Guilherme
dc.contributor.authorMargarit, Sonia
dc.contributor.authorFernández, Ricardo
dc.date.accessioned2025-01-09T14:32:25Z
dc.date.available2025-01-09T14:32:25Z
dc.date.issued2024
dc.description.abstractOral squamous cell carcinoma (OSCC) has a poor prognosis and the treatment employed generates significant physical deformity in patients. In recent years, an increase in the incidence of cases of OSCC has been observed in adult patients up to 45 years old in several genetic underrepresented and underserved countries. The increase in OSCC cases in young people is very relevant because it shows that OSCC does not make exceptions and hereditarily must play an important role. This fact has not been associated with an evident biological basis, and a large majority of these patients do not present the classic principal risk factors association. OSCC is the result of accumulation of genetic and epigenetic alterations and this information is still fragmented in the literature, mainly in the young group. Conducting studies with a comprehensive analysis of genetic and epigenetic data is crucial, to provide greater understanding of the underlying biology of OSCC, because this information can be decisive to determine targets for therapeutic treatment. We review the main germline and somatic aspects of genetic and genomic variation in OSCC considering the absence of genomic data from developing countries such as Chile and the rest of Hispano-America.
dc.description.versionVersión Aceptada
dc.identifier.citationAdorno-Farias D, Morales-Pisón S, Gischkow-Rucatti G, Margarit S, Fernández-Ramires R. Genetic and epigenetic landscape of early-onset oral squamous cell carcinoma: Insights of genomic underserved and underrepresented populations. Genet Mol Biol. 2024 Aug 5;47Suppl 1(Suppl 1):e20240036. doi: 10.1590/1678-4685-GMB-2024-0036.
dc.identifier.doihttps://doi.org/10.1590/1678-4685-GMB-2024-0036
dc.identifier.urihttps://hdl.handle.net/11447/9597
dc.language.isoen
dc.subjectGenetic
dc.subjectEpigenetic
dc.subjectYoung patients
dc.subjectOral squamous cell carcinoma
dc.titleGenetic and epigenetic landscape of early-onset oral squamous cell carcinoma: Insights of genomic underserved and underrepresented populations
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceGenetics and molecular biology
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Genetic and epigenetic landscape of early-onset oral squamous cell carcinoma.pdf
Size:
974.93 KB
Format:
Adobe Portable Document Format
Description:
Texto Completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services