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The value of Clinical signs in the diagnosis of Degenerative Cervical Myelopathy - A Systematic review and Meta-analysis

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dc.contributor.authorJiang, Zhilin
dc.contributor.authorDavies, Benjamin
dc.contributor.authorZipser, Carl
dc.contributor.authorMargetis, Konstantinos
dc.contributor.authorMartin, Allan
dc.contributor.authorMatsoukas, Stavros
dc.contributor.authorZipser, Freschta
dc.contributor.authorKheram, Najmeh
dc.contributor.authorBoraschi, Andrea
dc.contributor.authorZakin, Elina
dc.contributor.authorRighteous, Oke
dc.contributor.authorFehlings, Michael
dc.contributor.authorWilson, Jamie
dc.contributor.authorYurac, Ratko
dc.contributor.authorCook, Chad
dc.contributor.authorMilligan, Jamie
dc.contributor.authorTabrah, Julia
dc.contributor.authorWiddop, Shirley
dc.contributor.authorWood, Lianne
dc.contributor.authorRoberts, Elizabeth
dc.contributor.authorRujeedawa, Tanzil
dc.contributor.authorTetreault, Lindsay
dc.contributor.authorAO Spine RECODE-DCM Diagnostic Criteria Incubator
dc.date.accessioned2024-04-22T21:57:58Z
dc.date.available2024-04-22T21:57:58Z
dc.date.issued2023
dc.description.abstractStudy design: Delayed diagnosis of degenerative cervical myelopathy (DCM) is likely due to a combination of its subtle symptoms, incomplete neurological assessments by clinicians and a lack of public and professional awareness. Diagnostic criteria for DCM will likely facilitate earlier referral for definitive management. Objectives: This systematic review aims to determine (i) the diagnostic accuracy of various clinical signs and (ii) the association between clinical signs and disease severity in DCM? Methods: A search was performed to identify studies on adult patients that evaluated the diagnostic accuracy of a clinical sign used for diagnosing DCM. Studies were also included if they assessed the association between the presence of a clinical sign and disease severity. The QUADAS-2 tool was used to evaluate the risk of bias of individual studies. Results: This review identified eleven studies that used a control group to evaluate the diagnostic accuracy of various signs. An additional 61 articles reported on the frequency of clinical signs in a cohort of DCM patients. The most sensitive clinical tests for diagnosing DCM were the Tromner and hyperreflexia, whereas the most specific tests were the Babinski, Tromner, clonus and inverted supinator sign. Five studies evaluated the association between the presence of various clinical signs and disease severity. There was no definite association between Hoffmann sign, Babinski sign or hyperreflexia and disease severity. Conclusion: The presence of clinical signs suggesting spinal cord compression should encourage health care professionals to pursue further investigation, such as neuroimaging to either confirm or refute a diagnosis of DCM.
dc.description.versionPublicada
dc.identifier.citationJiang Z, Davies B, Zipser C, Margetis K, Martin A, Matsoukas S, Zipser-Mohammadzada F, Kheram N, Boraschi A, Zakin E, Obadaseraye OR, Fehlings MG, Wilson J, Yurac R, Cook CE, Milligan J, Tabrah J, Widdop S, Wood L, Roberts EA, Rujeedawa T, Tetreault L; AO Spine RECODE-DCM Diagnostic Criteria Incubator. The value of Clinical signs in the diagnosis of Degenerative Cervical Myelopathy - A Systematic review and Meta-analysis. Global Spine J. 2023 Oct 30:21925682231209869. doi: 10.1177/21925682231209869
dc.identifier.doihttps://doi.org/10.1177/21925682231209869
dc.identifier.urihttps://hdl.handle.net/11447/8669
dc.language.isoen
dc.subjectCervical
dc.subjectDegenerative disc disease
dc.subjectMyelopathy
dc.titleThe value of Clinical signs in the diagnosis of Degenerative Cervical Myelopathy - A Systematic review and Meta-analysis
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceGlobal spine journal
dspace.entity.typePublication
relation.isAuthorOfPublication631830b2-9e94-4f76-bf44-70d266274dbc
relation.isAuthorOfPublication.latestForDiscovery631830b2-9e94-4f76-bf44-70d266274dbc

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