Publication:
Key Role of Astrocytes in Postnatal Brain and Retinal Angiogenesis

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dc.contributor.authorPuebla, Mariela
dc.contributor.authorTapia, Pablo J.
dc.contributor.authorEspinoza, Hilda
dc.date.accessioned2023-07-07T17:17:33Z
dc.date.available2023-07-07T17:17:33Z
dc.date.issued2022
dc.description.abstractAngiogenesis is a key process in various physiological and pathological conditions in the nervous system and in the retina during postnatal life. Although an increasing number of studies have addressed the role of endothelial cells in this event, the astrocytes contribution in angiogenesis has received less attention. This review is focused on the role of astrocytes as a scaffold and in the stabilization of the new blood vessels, through different molecules release, which can modulate the angiogenesis process in the brain and in the retina. Further, differences in the astrocytes phenotype are addressed in glioblastoma, one of the most devastating types of brain cancer, in order to provide potential targets involved in the cross signaling between endothelial cells, astrocytes and glioma cells, that mediate tumor progression and pathological angiogenesis. Given the relevance of astrocytes in angiogenesis in physiological and pathological conditions, future studies are required to better understand the interrelation between endothelial and astrocyte signaling pathways during this process.
dc.description.versionVersión publicada
dc.format.extent22 p.
dc.identifier.citationInt J Mol Sci. 2022 Feb 28;23(5):2646.
dc.identifier.doihttps://doi.org/10.3390/ijms23052646
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7663
dc.language.isoen
dc.subjectBrain angiogenesis
dc.subjectRetinal angiogenesis
dc.subjectAstrocytes
dc.subjectEndothelial cells
dc.subjectExtracellular matrix
dc.titleKey Role of Astrocytes in Postnatal Brain and Retinal Angiogenesis
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceInternational Journal of Molecular Sciences
dspace.entity.typePublication

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