Publication:
Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis

Simple item page
dc.contributor.authorRamírez, Juan
dc.contributor.authorTepper, Ángeles
dc.contributor.authorAlliende, Luz
dc.contributor.authorMena, Carlos
dc.contributor.authorCastañeda, Carmen
dc.contributor.authorIruretagoyena, Bárbara
dc.contributor.authorNachar, Ruben
dc.contributor.authorReyes, Francisco
dc.contributor.authorLeón, Pablo
dc.contributor.authorMora, Ricardo
dc.contributor.authorOssandon, Tomas
dc.contributor.authorGonzález, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorDe la Fuente, Camilo
dc.contributor.authorCrossley, Nicolas
dc.date.accessioned2023-04-14T16:42:46Z
dc.date.available2023-04-14T16:42:46Z
dc.date.issued2022
dc.description.abstractBackground and hypothesis: Abnormal functional connectivity between brain regions is a consistent finding in schizophrenia, including functional magnetic resonance imaging (fMRI) studies. Recent studies have highlighted that connectivity changes in time in healthy subjects. We here examined the temporal changes in functional connectivity in patients with a first episode of psychosis (FEP). Specifically, we analyzed the temporal order in which whole-brain organization states were visited. Study design: Two case-control studies, including in each sample a subgroup scanned a second time after treatment. Chilean sample included 79 patients with a FEP and 83 healthy controls. Mexican sample included 21 antipsychotic-naïve FEP patients and 15 healthy controls. Characteristics of the temporal trajectories between whole-brain functional connectivity meta-states were examined via resting-state functional MRI using elements of network science. We compared the cohorts of cases and controls and explored their differences as well as potential associations with symptoms, cognition, and antipsychotic medication doses. Study results: We found that the temporal sequence in which patients' brain dynamics visited the different states was more redundant and segregated. Patients were less flexible than controls in changing their network in time from different configurations, and explored the whole landscape of possible states in a less efficient way. These changes were related to the dose of antipsychotics the patients were receiving. We replicated the relationship with antipsychotic medication in the antipsychotic-naïve FEP sample scanned before and after treatment. Conclusions: We conclude that psychosis is related to a temporal disorganization of the brain's dynamic functional connectivity, and this is associated with antipsychotic medication use.
dc.description.versionVersión enviada
dc.identifier.citationRamirez-Mahaluf JP, Tepper Á, Alliende LM, Mena C, Castañeda CP, Iruretagoyena B, Nachar R, Reyes-Madrigal F, León-Ortiz P, Mora-Durán R, Ossandon T, Gonzalez-Valderrama A, Undurraga J, de la Fuente-Sandoval C, Crossley NA. Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis. Schizophr Bull. 2022 Dec 6:sbac187. doi: 10.1093/schbul/sbac187
dc.identifier.doihttps://doi.org/10.1093/schbul/sbac187
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7334
dc.language.isoen
dc.subjectAntipsychotic
dc.subjectBrain networks
dc.subjectDynamic connectivity
dc.subjectGraph analysis
dc.subjectMeta-states
dc.titleDysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceSchizophrenia bulletin
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
4. Dysconnectivity in schizophrenia revisited.pdf
Size:
2.63 MB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services