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Acute activation of hemichannels by ethanol leads to Ca2+ -dependent gliotransmitter release in astrocytes

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dc.contributor.authorGómez, Gonzalo I.
dc.contributor.authorGarcía-Rodríguez, Claudia
dc.contributor.authorMarillán, Jesús E.
dc.contributor.authorVergara, Sergio A.
dc.contributor.authorAlvear, Tanhia F.
dc.contributor.authorFarias-Pasten, Arantza
dc.contributor.authorSáez, Juan C.
dc.contributor.authorRetamal, Mauricio A.
dc.contributor.authorRovegno, Maximiliano
dc.contributor.authorOrtiz, Fernando C.
dc.contributor.authorOrellana, Juan A.
dc.date.accessioned2024-12-23T19:51:59Z
dc.date.available2024-12-23T19:51:59Z
dc.date.issued2024
dc.description.abstractMultiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood. Astrocyte-mediated gliotransmission is crucial for hippocampal plasticity, and recently, the opening of hemichannels has been found to play a relevant role in this process. Hemichannels are plasma membrane channels composed of six connexins or seven pannexins, respectively, that oligomerize around a central pore. They serve as ionic and molecular exchange conduits between the cytoplasm and extracellular milieu, allowing the release of various paracrine substances, such as ATP, D-serine, and glutamate, and the entry of ions and other substances, such as Ca2+ and glucose. The persistent and exacerbated opening of hemichannels has been associated with the pathogenesis and progression of several brain diseases for at least three mechanisms.
dc.description.versionVersión publicada
dc.format.extent15 p.
dc.identifier.citationGómez GI, García-Rodríguez C, Marillán JE, Vergara SA, Alvear TF, Farias-Pasten A, Sáez JC, Retamal MA, Rovegno M, Ortiz FC and Orellana JA (2024), Acute activation of hemichannels by ethanol leads to Ca2+- dependent gliotransmitter release in astrocytes. Front. Cell Dev. Biol. 12:1422978. doi: 10.3389/fcell.2024.1422978
dc.identifier.doihttps://doi.org/10.3389/fcell.2024.1422978
dc.identifier.urihttps://hdl.handle.net/11447/9523
dc.language.isoes
dc.subjectAlcoholism
dc.subjectConnexins
dc.subjectPannexins
dc.subjectGlia
dc.subjectHemichannels
dc.titleAcute activation of hemichannels by ethanol leads to Ca2+ -dependent gliotransmitter release in astrocytes
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceFrontiers in Cell and Developmental Biology
dspace.entity.typePublication
relation.isAuthorOfPublication01e4a6fa-e55f-47c5-a1b6-383d5fc6f474
relation.isAuthorOfPublication.latestForDiscovery01e4a6fa-e55f-47c5-a1b6-383d5fc6f474

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