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Connexins in Cancer, the Possible Role of Connexin46 as a Cancer Stem Cell-Determining Protein

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dc.contributor.authorLeón, Isidora
dc.contributor.authorSalgado, María
dc.contributor.authorNovoa, María
dc.contributor.authorRetamal, Mauricio A.
dc.date.accessioned2024-01-10T14:54:11Z
dc.date.available2024-01-10T14:54:11Z
dc.date.issued2023
dc.description.abstractCancer is a widespread and incurable disease caused by genetic mutations, leading to uncontrolled cell proliferation and metastasis. Connexins (Cx) are transmembrane proteins that facilitate intercellular communication via hemichannels and gap junction channels. Among them, Cx46 is found mostly in the eye lens. However, in pathological conditions, Cx46 has been observed in various types of cancers, such as glioblastoma, melanoma, and breast cancer. It has been demonstrated that elevated Cx46 levels in breast cancer contribute to cellular resistance to hypoxia, and it is an enhancer of cancer aggressiveness supporting a pro-tumoral role. Accordingly, Cx46 is associated with an increase in cancer stem cell phenotype. These cells display radio- and chemoresistance, high proliferative abilities, self-renewal, and differentiation capacities. This review aims to consolidate the knowledge of the relationship between Cx46, its role in forming hemichannels and gap junctions, and its connection with cancer and cancer stem cells.
dc.description.versionVersión Publicada
dc.identifier.citationLeón-Fuentes IM, Salgado-Gil MG, Novoa MS, Retamal MA. Connexins in Cancer, the Possible Role of Connexin46 as a Cancer Stem Cell-Determining Protein. Biomolecules. 2023 Sep 27;13(10):1460. doi: 10.3390/biom13101460
dc.identifier.doihttps://doi.org/10.3390/biom13101460
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/8323
dc.language.isoen
dc.subjectConnexin46
dc.subjectGJA3
dc.subjectbreast cancer
dc.subjectCancer stem cells
dc.subjectGap junction channels
dc.titleConnexins in Cancer, the Possible Role of Connexin46 as a Cancer Stem Cell-Determining Protein
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceBiomolecules
dspace.entity.typePublication
relation.isAuthorOfPublication01e4a6fa-e55f-47c5-a1b6-383d5fc6f474
relation.isAuthorOfPublication.latestForDiscovery01e4a6fa-e55f-47c5-a1b6-383d5fc6f474

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