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Oxidative Stress in Polycystic Ovary Syndrome: Impact of Combined Oral Contraceptives

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dc.contributor.authorSantander, Nicolás
dc.contributor.authorFigueroa, Esteban
dc.contributor.authorGonzález, Alejandro
dc.contributor.authorMaliqueo, Manuel
dc.contributor.authorEchiburú, Bárbara
dc.contributor.authorCrisosto, Nicolás
dc.contributor.authorSalas, Francisca
dc.date.accessioned2025-01-21T20:09:14Z
dc.date.available2025-01-21T20:09:14Z
dc.date.issued2024
dc.description.abstractPolycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that is associated with heightened metabolic risks. While oxidative stress (OS) is known to play a role in PCOS, the precise nature of the relationship between PCOS and increased OS remains not entirely understood. Combined oral contraceptives (COCs) are the first-line treatment to regulate menstrual cycles and androgen levels, but their impact on oxidative stress requires further study. We conducted a transcriptomic analysis using RNAseq and assessed the levels of various oxidative stress (OS) markers in serum samples from women with PCOS and controls and whether they were using combined oral contraceptives (COCs), including enzymatic activities, FRAP, and 8-isoprostane (8-iso). A total of 359 genes were differentially expressed in women with PCOS compared to control women. Genes differentially expressed were enriched in functions related to inflammation and, interestingly, oxidative stress response. In controls, 8-iso levels were increased in women using COCs, whereas in women with PCOS, 8-iso levels were reduced in those using oral contraceptives (191.1 ± 97 vs. 26.4 ± 21 pg/mL, p: <0.0001). Correlation analyses showed a trend for a negative correlation between 8-iso and Ferriman score in women with PCOS consuming COCs (r = -0.86, p = 0.06) and a negative correlation between GSH and hyperandrogenism in women with PCOS (r = -0.89, p = 0.01). These results reveal the presence of lipid peroxidation in women with PCOS, which was modified by the use of COCs, providing new insights into the pathophysiology of PCOS in the Chilean population.
dc.description.versionVersión Publicada
dc.identifier.citationSantander N, Figueroa EG, González-Candia A, Maliqueo M, Echiburú B, Crisosto N, Salas-Pérez F. Oxidative Stress in Polycystic Ovary Syndrome: Impact of Combined Oral Contraceptives. Antioxidants (Basel). 2024 Sep 26;13(10):1168. doi: 10.3390/antiox13101168
dc.identifier.doihttps://doi.org/10.3390/antiox13101168
dc.identifier.urihttps://hdl.handle.net/11447/9691
dc.language.isoen
dc.subjectMetabolism
dc.subjectContraception
dc.subjectHormones
dc.subjectCardiovascular risk
dc.titleOxidative Stress in Polycystic Ovary Syndrome: Impact of Combined Oral Contraceptives
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceAntioxidants
dspace.entity.typePublication

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