Clinical, immunologic, and genetic characteristics of 148 patients with natural killer cell deficiency

Abdalgani, Manar; Hernandez , Evelyn; Pedroza, Luis; Chinn, Ivan; Forbes, Lisa; Rider, Nicholas; Banerjee, Pinaki; Poli Harlowe, María Cecilia; Mahapatra, Sanjana; Canter, Debra; Cao, Tram; Shawver, Linda; Nandiwada, Sarada; Lupski, James; Posey, Jennifer; Ramakrishnan, Rajasekhar; Mace, Emily; Orange, Jordan

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Clinical, immunologic, and genetic characteristics of 148 patients with natural killer cell deficiency

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Clinical, immunologic, and genetic characteristics of 148 patients with natural killer cell deficiency.pdf (2.01 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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1

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Authors

Poli Harlowe, María Cecilia

Mahapatra, Sanjana

Canter, Debra

item.page.doiurl

https://doi.org/10.1016/j.jaci.2025.01.030

URI

https://hdl.handle.net/11447/11006

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Abstract

Background: Natural killer (NK) cell deficiency (NKD) is an immunodeficiency phenotype in which abnormality of NK cells is the major clinically relevant immune defect. Objective: We sought to define ...

Citation

Abdalgani M, Hernandez ER, Pedroza LA, Chinn IK, Forbes Satter LR, Rider NL, Banerjee PP, Poli MC, Mahapatra S, Canter D, Cao T, Shawver LM, Nandiwada SL, Lupski JR, Posey JE, Ramakrishnan R, Mace EM, Orange JS. Clinical, immunologic, and genetic characteristics of 148 patients with natural killer cell deficiency. J Allergy Clin Immunol. 2025 May;155(5):1623-1634. doi: 10.1016/j.jaci.2025.01.030

Keywords

NK cells , cytotoxicity , immunogenetics , gene pathogenic alleles , herpesvirus , inborn errors of immunity , primary immunodeficiency

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