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Post-COVID-19 condition: a sex-based analysis of clinical and laboratory trends

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dc.contributor.authorDelfino, Carlos
dc.contributor.authorPoli Harlowe, María Cecilia
dc.contributor.authorVial Cox, María Cecilia
dc.contributor.authorVial, Pablo
dc.contributor.authorMartínez, Gonzalo
dc.contributor.authorRiviotta, Amy
dc.contributor.authorArbat, Catalina
dc.contributor.authorMac-Guire, Nicole
dc.contributor.authorHoppe, Josefina
dc.contributor.authorCarvajal, Cristóbal
dc.contributor.authorMunoz Venturelli, Paula
dc.date.accessioned2025-01-13T17:18:38Z
dc.date.available2025-01-13T17:18:38Z
dc.date.issued2024
dc.description.abstractBackground and aim: Post-COVID-19 condition (PCC) encompasses long-lasting symptoms in individuals with COVID-19 and is estimated to affect between 31-67% of patients, with women being more commonly affected. No definitive biomarkers have emerged in the acute stage that can help predict the onset of PCC, therefore we aimed at describing sex-disaggregated data of PCC patients from a local cohort and explore potential acute predictors of PCC and neurologic PCC. Methods: A local cohort of consecutive patients admitted with COVID-19 diagnosis between June 2020 and July 2021 were registered, and clinical and laboratory data were recorded. Only those <65 years, discharged alive and followed up at 6 and 12 months after admission were considered in these analyses. Multivariable logistic regression analysis was performed to explore variables associated with PCC (STATA v 18.0). Results: From 130 patients in the cohort, 104 were contacted: 30% were women, median age of 42 years. At 6 months, 71 (68%) reported PCC symptoms. Women exhibited a higher prevalence of any PCC symptom (87 vs. 60%, p = 0.007), lower ferritin (p = 0.001) and procalcitonin (p = 0.021) and higher TNF levels (p = 0.042) in the acute phase compared to men. Being women was independently associated to 7.60 (95% CI 1.27-45.18, p = 0.026) higher risk for PCC. Moreover, women had lower return to normal activities 6 and 12 months. Conclusion: Our findings highlight the lasting impact of COVID-19, particularly in young women, emphasising the need for tailored post-COVID care. The lower ferritin levels in women are an intriguing observation, warranting further research. The study argues for comprehensive strategies that address sex-specific challenges in recovery from COVID-19.
dc.description.versionVersión Publicada
dc.identifier.citationDelfino C, Poli MC, Vial C, Vial PA, Martínez G, Riviotta A, Arbat C, Mac-Guire N, Hoppe J, Carvajal C, Muñoz Venturelli P. Post-COVID-19 condition: a sex-based analysis of clinical and laboratory trends. Front Med (Lausanne). 2024 Jun 7;11:1376030. doi: 10.3389/fmed.2024.1376030
dc.identifier.doihttps://doi.org/10.3389/fmed.2024.1376030
dc.identifier.urihttps://hdl.handle.net/11447/9633
dc.language.isoen
dc.subjectCOVID-19
dc.subjectLong COVID
dc.subjectNeurologic long-COVID-19
dc.subjectPost COVID-19 condition
dc.subjectSex-disaggregated
dc.titlePost-COVID-19 condition: a sex-based analysis of clinical and laboratory trends
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceFrontiers in medicine
dspace.entity.typePublication
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