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Review of techniques useful for the assessment of sensory small fiber neuropathies: Report from an IFCN expert group.

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dc.contributor.authorVerdugo, Renato
dc.contributor.authorMatamala, José
dc.contributor.authorInui, Koji
dc.contributor.authorKakigi, Ryusuke
dc.contributor.authorValls-Solé, Josep
dc.contributor.authorHansson, Per
dc.contributor.authorNilsen, Kristian Bernhard
dc.contributor.authorLombardi, Raffaella
dc.contributor.authorLauria, Giuseppe
dc.contributor.authorPetropoulos, Ioannis N.
dc.contributor.authorMalik, Rayaz A.
dc.contributor.authorTreede, Rolf-Detlef
dc.contributor.authorBaumgärtner, Ulf
dc.contributor.authorJara, Paula A.
dc.contributor.authorCampero, Mario
dc.date.accessioned2023-07-07T17:03:50Z
dc.date.available2023-07-07T17:03:50Z
dc.date.issued2022
dc.description.abstractNerve conduction studies (NCS) are an essential aspect of the assessment of patients with peripheral neuropathies. However, conventional NCS do not reflect activation of small afferent fibers, including Aδ and C fibers. A definitive gold standard for laboratory evaluation of these fibers is still needed and therefore, clinical evaluation remains fundamental in patients with small fiber neuropathies (SFN). Several clinical and research techniques have been developed for the assessment of small fiber function, such as (i) microneurography, (ii) laser evoked potentials, (iii) contact heat evoked potentials, (iv) pain-related electrically evoked potentials, (v) quantitative thermal sensory testing, (vi) skin biopsy-intraepidermal nerve fiber density and (vii) corneal confocal microscopy. The first five are physiological techniques, while the last two are morphological. They all have advantages and limitations, but the combined use of an appropriate selection of each of them would lead to gathering invaluable information for the diagnosis of SFN. In this review, we present an update on techniques available for the study of small afferent fibers and their clinical applicability. A summary of the anatomy and important physiological aspects of these pathways, and the clinical manifestations of their dysfunction is also included, in order to have a minimal common background.
dc.description.versionVersión publicada
dc.format.extent26 p.
dc.identifier.citationClin Neurophysiol. 2022 Apr;136:13-38.
dc.identifier.doihttps://doi.org/10.1016/j.clinph.2022.01.002
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7661
dc.language.isoen
dc.subjectSensory small fibers
dc.subjectAδ fibers
dc.subjectC fibers
dc.subjectNeurophysiological assessment
dc.titleReview of techniques useful for the assessment of sensory small fiber neuropathies: Report from an IFCN expert group.
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceClinical Neurophysiology
dspace.entity.typePublication

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