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Long-term effects of COVID-19 in patients with primary immunodeficiency: An IPOPI worldwide survey

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dc.contributor.authorVan Leeuwen, Leanne
dc.contributor.authorVan Coillie, Samya
dc.contributor.authorPrévot, Johan
dc.contributor.authorDrabwell, Jose
dc.contributor.authorMahlaoui, Nizar
dc.contributor.authorSánchez-Ramón, Silvia
dc.contributor.authorPoli Harlowe, María Cecilia
dc.contributor.authorMeyts, Isabelle
dc.contributor.authorAli, Adli
dc.contributor.authorLowe, David
dc.contributor.authorDalm, Virgil
dc.contributor.authorPergent, Martine
dc.date.accessioned2026-08-19T16:09:56Z
dc.date.available2026-08-19T16:09:56Z
dc.date.issued2025
dc.description.abstractBackground: During the coronavirus disease 2019 (COVID-19) pandemic, many individuals developed persistent symptoms after COVID-19. The data on these long-term effects in the primary immunodeficiency (PID) community are limited. Objective: This study aimed to understand long-term symptoms after COVID-19 in patients with PID, focusing on prevalence, risk factors, viral persistence, and the impact of COVID-19 on their health-related quality of life (HR-QoL). Methods: A global, multilingual web-based survey was conducted by the International Patient Organization for Primary Immunodeficiencies between July and October 2023. Self-reported data on demographics, PID diagnosis, comorbidities, COVID-19, and HR-QoL were collected using the EuroQol 5-Dimensions 5-Level (EQ-5D-5L) survey and analyzed. Results: Of the 1160 respondents, 25% reported persistent symptoms after COVID-19. Common symptoms included fatigue, headache, and nasal symptoms. Compared with those respondents without persistent symptoms, those with persistent symptoms after COVID-19 reported a significantly higher prevalence of symptoms across all categories-systemic, pain, cardiopulmonary, gastrointestinal, neurologic, psychological, neurocognitive, and others-except for upper respiratory tract symptoms. Independent risk factors for development of persistent symptoms included female sex, asthma, neurologic diseases, and predominantly antibody deficiency other than common variable immunodeficiency or agammaglobulinemia. In 30% of patients with persistent symptoms, viral clearance was not achieved within 1 month. During the pandemic, HR-QoL declined across all PID categories-even in those without COVID-19, but especially in those with a symptom duration of more than 6 months. Conclusion: Persistent symptoms after COVID-19 are prevalent among patients with PID, with various risk factors identified. The COVID-19 pandemic had a considerable impact on the HR-QoL of patients with PID regardless of COVID-19 status.
dc.description.versionVersión Publicada
dc.identifier.citationVan Leeuwen LPM, Van Coillie S, Prévot J, Drabwell J, Mahlaoui N, Sánchez-Ramón S, Poli MC, Meyts I, Ali A, Lowe DM, Dalm VASH, Pergent M. Long-term effects of COVID-19 in patients with primary immunodeficiency: An IPOPI worldwide survey. J Allergy Clin Immunol. 2025 Aug;156(2):449-462. doi: 10.1016/j.jaci.2025.04.023.
dc.identifier.doihttps://doi.org/10.1016/j.jaci.2025.04.023
dc.identifier.urihttps://hdl.handle.net/11447/11022
dc.language.isoen
dc.subjectCOVID-19
dc.subjectHR-QoL
dc.subjectPID
dc.subjectHealth-related quality of life
dc.subjectLong COVID
dc.subjectPatient-reported
dc.subjectPersistent symptoms
dc.subjectPrimary immunodeficiencies
dc.subjectsurvey
dc.subjectviral persistence
dc.titleLong-term effects of COVID-19 in patients with primary immunodeficiency: An IPOPI worldwide survey
dc.typeArticle
dcterms.sourceThe Journal of allergy and clinical immunology
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoverybf711dbf-cd6f-4a66-97fb-64c15f664de3

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