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Chronic Stress and Ovulatory Dysfunction: Implications in Times of COVID-19

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dc.contributor.authorVigil, Pilar
dc.contributor.authorMeléndez, Jaime
dc.contributor.authorSoto, Hugo
dc.contributor.authorPetkovic, Grace
dc.contributor.authorBernal, Yanara
dc.contributor.authorMolina, Santiago
dc.date.accessioned2023-05-04T15:51:21Z
dc.date.available2023-05-04T15:51:21Z
dc.date.issued2022
dc.description.abstractStress is known to be associated with adverse health outcomes. The COVID-19 pandemic and its associated lockdowns are examples of chronic stressors. Lockdown measures inadvertently caused significant psychological distress and became a powerful source of anxiety/stress, sleep disturbances, nutritional changes and weight gain. Stress is known to impact women's health specifically, through hypothalamic-pituitary-gonadal (HPG) axis dysfunction and resultant ovulatory dysfunction. Such dysfunction may manifest in menstrual irregularities and/or infertility due to hypothalamic hypogonadism. Here, we review the key physiological mediators of stress and associated ovulatory dysfunction. The kisspeptinergic system is comprised of sets of neurons located in the hypothalamus, the rostral periventricular region of the third ventricle (RP3V) and the arcuate nucleus (ARC). This system links nutrition, reproductive signals and stress. It plays a key role in the function of the HPG axis. During chronic stress, the kisspeptinergic system affects the HPG axis, GnRH pulsatility, and, therefore, ovulation. Leptin, insulin and corticotrophin-releasing hormone (CRH) are thought to be additional key modulators in the behavioral responses to chronic stress and may contribute to stress-related ovulatory dysfunction. This mini-review also summarizes and appraises the available evidence on the negative impact of chronic stress as a result of the COVID-19 pandemic lockdowns. It proposes physiological mechanisms to explain the observed effects on women's reproductive health and well-being. The review suggests areas for future research.
dc.identifier.citationVigil P, Meléndez J, Soto H, Petkovic G, Bernal YA, Molina S. Chronic Stress and Ovulatory Dysfunction: Implications in Times of COVID-19. Front Glob Womens Health. 2022 May 23;3:866104. doi: 10.3389/fgwh.2022.866104
dc.identifier.doihttps://doi.org/10.3389/fgwh.2022.866104
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7455
dc.language.isoen
dc.subjectMenstrual cycle
dc.subjectKisspeptin
dc.subjectObesity
dc.subjectStress
dc.subjectAnxiety
dc.subjectOvulation
dc.titleChronic Stress and Ovulatory Dysfunction: Implications in Times of COVID-19
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceFrontiers in Global Women’s Health
dspace.entity.typePublication

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