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Targeting earlier diagnosis: What symptoms come first in Degenerative Cervical Myelopathy?

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dc.contributor.authorMunro, Colin
dc.contributor.authorYurac, Ratko
dc.contributor.authorCarl, Zipser
dc.contributor.authorFehlings, Michael
dc.contributor.authorRodrigues, Ricardo
dc.contributor.authorMilligan, James
dc.contributor.authorMargetis , Konstantinos
dc.contributor.authorKotter, Mark
dc.contributor.authorDavies, Benjamin
dc.date.accessioned2024-04-16T21:55:55Z
dc.date.available2024-04-16T21:55:55Z
dc.date.issued2023
dc.description.abstractBackground: Degenerative cervical myelopathy (DCM) is a common and disabling condition. Early effective treatment is limited by late diagnosis. Conventional descriptions of DCM focus on motor and sensory limb disability, however, recent work suggests the true impact is much broader. This study aimed to characterise the symptomatic presentation of DCM from the perspective of people with DCM and determine whether any of the reported symptoms, or groups of symptoms, were associated with early diagnosis. Methods: An internet survey was developed, using an established list of patient-reported effects. Participants (N = 171) were recruited from an online community of people with DCM. Respondents selected their current symptoms and primary presenting symptom. The relationship of symptoms and their relationship to time to diagnosis were explored. This included symptoms not commonly measured today, termed 'non-conventional' symptoms. Results: All listed symptoms were experienced by >10% of respondents, with poor balance being the most commonly reported (84.2%). Non-conventional symptoms accounted for 39.7% of symptomatic burden. 55.4% of the symptoms were reported as an initial symptom, with neck pain the most common (13.5%). Non-conventional symptoms accounted for 11.1% of initial symptoms. 79.5% of the respondents were diagnosed late (>6 months). Heavy legs was the only initial symptom associated with early diagnosis. Conclusions: A comprehensive description of the self-reported effects of DCM has been established, including the prevalence of symptoms at disease presentation. The experience of DCM is broader than suggested by conventional descriptions and further exploration of non-conventional symptoms may support earlier diagnosis.
dc.description.versionPublicada
dc.identifier.citationMunro CF, Yurac R, Moritz ZC, Fehlings MG, Rodrigues-Pinto R, Milligan J, Margetis K, Kotter MRN, Davies BM. Targeting earlier diagnosis: What symptoms come first in Degenerative Cervical Myelopathy? PLoS One. 2023 Mar 31;18(3):e0281856. doi: 10.1371/journal.pone.0281856
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0281856
dc.identifier.urihttps://hdl.handle.net/11447/8634
dc.language.isoen
dc.subjectCervical Vertebrae
dc.subjectDelayed Diagnosis
dc.subjectHumans
dc.subjectNeck
dc.subjectNeck Pain
dc.subjectSpinal Cord Diseases
dc.titleTargeting earlier diagnosis: What symptoms come first in Degenerative Cervical Myelopathy?
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourcePloS one
dspace.entity.typePublication
relation.isAuthorOfPublication631830b2-9e94-4f76-bf44-70d266274dbc
relation.isAuthorOfPublication.latestForDiscovery631830b2-9e94-4f76-bf44-70d266274dbc

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