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Fish Oil Supplementation Attenuates Offspring's Neurodevelopmental Changes Induced by a Maternal High-Fat Diet in a Rat Model

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dc.contributor.authorMuñoz, Yasna
dc.contributor.authorKaune, Heidy
dc.contributor.authorDagnino, Alexies
dc.contributor.authorCruz, Gonzalo
dc.contributor.authorToledo, Jorge
dc.contributor.authorValenzuela, Rodrigo
dc.contributor.authorMoraga, Renato
dc.contributor.authorTabilo, Luis
dc.contributor.authorFlores, Cristian
dc.contributor.authorMuñoz, Alfredo
dc.contributor.authorCrisosto, Nicolás
dc.contributor.authorMontiel, Juan
dc.contributor.authorMaliqueo, Manuel
dc.date.accessioned2026-09-23T14:39:19Z
dc.date.available2026-09-23T14:39:19Z
dc.date.issued2025
dc.description.abstractBackground/Objectives: A maternal high-fat diet (HFD) impairs brain structure in offspring. In turn, fish oil (FO) rich in n-3 polyunsaturated fatty acids (PUFAs) has neuroprotective effects. Therefore, we investigated whether maternal HFD exposure affected the neurological reflexes, neuron morphology, and n-3 PUFA levels in the cerebral cortex of the offspring and whether these effects were mitigated by maternal FO consumption. Methods: Female Sprague Dawley rats received a control diet (CD, 10% Kcal fat) or HFD (45% Kcal fat) five weeks before mating and throughout pregnancy and lactation. From mating, a subgroup of HFD was supplemented with 11.4% FO into the diet (HFD-FO). Neurological reflexes were evaluated from postnatal day (PND) 3 until PND20. Brains were removed at PND22 for neuron morphology analysis. Moreover, fatty acid composition and transcripts of genes encoding for factors associated with synapse transmission (SNAP-25), plasticity (BDNF), transport of DHA (MFSD2a), and inflammation (NF-κB and IL-1β) were quantified in prefrontal, motor, and auditory cortices. Results: FO diminished the effects of HFD on the number of thin and mushroom-shaped dendritic spines in the cerebral cortex in both sexes. It also reversed the HFD effects on the motor and auditory reflexes in female and male offspring, respectively. In males, FO up-regulated Bdnf transcript levels in the motor cortex compared with CD and HFD. In females, n-3 PUFAs were higher in HFD and HFD-FO than in CD in the auditory cortex. Conclusions: Our results highlight the protective role of maternal dietary n-3 PUFAs in counteracting the effects induced by HFD on the acquisition of neurological reflexes and neuronal morphology in the cerebral cortex of the offspring of both sexes.
dc.description.versionVersión Publicada
dc.identifier.citationMuñoz, Y., Kaune, H., Dagnino-Subiabre, A., Cruz, G., Toledo, J., Valenzuela, R., Moraga, R., Tabilo, L., Flores, C., Muñoz, A., Crisosto, N., Montiel, J. F., & Maliqueo, M. (2025). Fish Oil Supplementation Attenuates Offspring's Neurodevelopmental Changes Induced by a Maternal High-Fat Diet in a Rat Model. Nutrients, 17(10), 1741. https://doi.org/10.3390/nu17101741
dc.identifier.doihttps://doi.org/10.3390/nu17101741
dc.identifier.urihttps://hdl.handle.net/11447/11171
dc.language.isoen
dc.subjectBrain cortex
dc.subjectDevelopment
dc.subjectfish oil
dc.subjectHigh-fat diet
dc.subjectNeurological reflexes
dc.titleFish Oil Supplementation Attenuates Offspring's Neurodevelopmental Changes Induced by a Maternal High-Fat Diet in a Rat Model
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceNutrients
dspace.entity.typePublication

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