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High-resolution manometry thresholds and motor patterns among asymptomatic individuals.

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dc.contributor.authorRengarajan, Arvind
dc.contributor.authorRogers, Benjamin D.
dc.contributor.authorWong, Zhiqin
dc.contributor.authorTolone, Salvatore
dc.contributor.authorSifrim, Daniel
dc.contributor.authorSerra, Jordi
dc.contributor.authorSavarino, Edoardo
dc.contributor.authorRoman, Sabine
dc.contributor.authorRemes-Troche, Jose M.
dc.contributor.authorRamos, Rosa
dc.contributor.authorPerez de la Serna, Julio
dc.contributor.authorPauwels, Ans
dc.contributor.authorLeguizamo, Ana Maria
dc.contributor.authorYeh Lee, Yeong
dc.contributor.authorKawamura, Osamu
dc.contributor.authorHayat, Jamal
dc.contributor.authorHani, Albis
dc.contributor.authorGonlachanvit, Sutep
dc.contributor.authorCisternas, Daniel
dc.contributor.authorCisternas, Daniel
dc.contributor.authorCarlson, Dustin
dc.contributor.authorBor, Serhat
dc.contributor.authorBhatia, Shobna
dc.contributor.authorAbrahao, Luiz
dc.contributor.authorPandolfino, John
dc.contributor.authorGyawali, C. Prakash
dc.date.accessioned2024-06-14T14:34:19Z
dc.date.available2024-06-14T14:34:19Z
dc.date.issued2022
dc.description.abstractObjective: High-resolution manometry (HRM) is the current standard for characterization of esophageal body and esophagogastric junction (EGJ) function. We aimed to examine the prevalence of abnormal esophageal motor patterns in health, and to determine optimal thresholds for software metrics across HRM systems. Design: Manometry studies from asymptomatic adults were solicited from motility centers worldwide, and were manually analyzed using integrated relaxation pressure (IRP), distal latency (DL), and distal contractile integral (DCI) in standardized fashion. Normative thresholds were assessed using fifth and/or 95th percentile values. Chicago Classification v3.0 criteria were applied to determine motor patterns across HRM systems, study positions (upright vs supine), ages, and genders. Results: Of 469 unique HRM studies (median age 28.0, range 18-79 years). 74.6% had a normal HRM pattern; none had achalasia. Ineffective esophageal motility (IEM) was the most frequent motor pattern identified (15.1% overall), followed by EGJ outflow obstruction (5.3%). Proportions with IEM were lower using stringent criteria (10.0%), especially in supine studies (7.1%-8.5%). Other motor patterns were rare (0.2%-4.1% overall) and did not vary by age or gender. DL thresholds were close to current norms across HRM systems, while IRP thresholds varied by HRM system and study position. Both fifth and 95th percentile DCI values were lower than current thresholds, both in upright and supine positions. Conclusions: Motor abnormalities are infrequent in healthy individuals and consist mainly of IEM, proportions of which are lower when using stringent criteria in the supine position. Thresholds for HRM metrics vary by HRM system and study position.
dc.description.versionVersión publicada
dc.format.extent9 p.
dc.identifier.citationClin Gastroenterol Hepatol. 2022 Mar;20(3)
dc.identifier.doihttps://doi.org/10.1016/j.cgh.2020.10.052
dc.identifier.urihttps://hdl.handle.net/11447/9097
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectDistal contractile integral
dc.subjectDistal latency
dc.subjectHigh-resolution manometry
dc.subjectIntegrated relaxation pressure
dc.titleHigh-resolution manometry thresholds and motor patterns among asymptomatic individuals.
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceClinical Gastroenterology and Hepatology
dspace.entity.typePublication
relation.isAuthorOfPublicatione1a01d35-b216-4a3e-bb07-f055e2f17eb9
relation.isAuthorOfPublication.latestForDiscoverye1a01d35-b216-4a3e-bb07-f055e2f17eb9

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