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Cardiovascular risk factors and the allostatic interoceptive network in dementia

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dc.contributor.authorHazelton, Jessica
dc.contributor.authorMigeot, Joaquín
dc.contributor.authorGonzalez, Raul
dc.contributor.authorAltschuler, Florencia
dc.contributor.authorDuran, Claudia
dc.contributor.authorWen, Olivia
dc.contributor.authorGalván, Dante
dc.contributor.authorBarttfeld, Pablo
dc.contributor.authorMedel , Vicente
dc.contributor.authorGonzález, Cecilia
dc.contributor.authorCastro, Ana
dc.contributor.authorHernández, Hernán
dc.contributor.authorGonzalez, Carolina
dc.contributor.authorCastaner, Olga
dc.contributor.authorHu, Kun
dc.contributor.authorLi, Peng
dc.contributor.authorMaria Isabel Behrens
dc.contributor.authorBehrens, Maria Isabel
dc.contributor.authorBruno, Martin
dc.contributor.authorCardona, Juan
dc.contributor.authorCustodio, Nilton
dc.contributor.authorSantamaria, Hernando
dc.contributor.authorGarcia, Adolfo
dc.contributor.authorGodoy, Maria
dc.contributor.authorAvila, José
dc.contributor.authorMaito, Marce
dc.contributor.authorMatallana, Diana
dc.contributor.authorMiller, Bruce
dc.contributor.authorLopera, Francisco
dc.contributor.authorOkada , Maira
dc.contributor.authorPina, Stefanie
dc.contributor.authorPossin, Katherine
dc.contributor.authorFrance, Elisa de Paula
dc.contributor.authorReyes, Pablo
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.contributor.authorSosa, Ana
dc.contributor.authorTakada, Leonel
dc.contributor.authorYokoyama, Jennifer
dc.contributor.authorIbanez, Agustin
dc.date.accessioned2026-08-03T16:32:12Z
dc.date.available2026-08-03T16:32:12Z
dc.date.issued2025
dc.description.abstractAims: Cardiovascular risk factors, such diabetes, hypertension, blood pressure, obesity, and smoking, are linked with allostatic-interoception-the continuous monitoring of internal bodily states in anticipation of environmental demands. These risk factors are associated with dementia risk. How these factors affect brain networks vulnerable to neurodegeneration and involved in allostatic-interoception, such as the Allostatic-Interoceptive Network (AIN), is unknown. We investigated the relationship between cardiovascular risk and AIN structure and function in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). Methods and results: We recruited 1501 participants (304 with FTLD, 512 with AD, and 685 healthy controls) from the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat). A cardiovascular risk score was calculated based on: age, sex, diabetes, hypertension, systolic blood pressure, body mass index, and smoking status. Cardiovascular risk was associated with grey matter integrity and functional connectivity in age- and sex-matched patient-control groups focusing on predefined regions of interest within the AIN. Higher cardiovascular risk was associated with reduced structural integrity and functional connectivity within the AIN in both FTLD and AD. FTLD patients showed more extensive structural and functional connectivity disruptions throughout the AIN. In AD patients, structural reductions in the AIN were prominent, with functional connectivity restricted to the hippocampus, parahippocampal gyrus, and orbitofrontal regions. Conclusion: Cardiovascular risk factors appear to adversely impact the AIN structure and function, with disease-specific patterns of vulnerability. Results underscore the importance of integrating cardiovascular health into models of neurodegenerative disease and managing cardiovascular health to support brain integrity in dementia.
dc.description.versionVersión Publicada
dc.identifier.citationHazelton JL, Migeot J, Gonzalez-Gomez R, Altschuler F, Duran-Aniotz C, Wen O, Galván Rial DSG, Barttfeld P, Medel V, Campo CG, Castro-Laguardia AM, Hernández H, Gonzalez-Silva C, Castaner O, Hu K, Li P, Behrens MI, Bruno MA, Cardona JF, Custodio N, Santamaria-Garcia H, Garcia AM, Godoy ME, Avila-Funes JA, Maito M, Matallana DL, Miller B, Lopera F, de Oliveira MO, Pina-Escudero SD, Possin KL, de Paula France Resende E, Reyes P, Slachevsky A, Sosa AL, Takada LT, Yokoyama JS, Ibanez A. Cardiovascular risk factors and the allostatic interoceptive network in dementia. Cardiovasc Res. 2025 Nov 22;121(14):2222-2232. doi: 10.1093/cvr/cvaf185
dc.identifier.doihttps://doi.org/10.1093/cvr/cvaf185
dc.identifier.urihttps://hdl.handle.net/11447/10943
dc.language.isoen
dc.subjectAging
dc.subjectBrain atrophy
dc.subjectCardiovascular health
dc.subjectCardiovascular risk
dc.subjectDementia
dc.subjectFunctional connectivity
dc.subjectNeurodegeneration
dc.titleCardiovascular risk factors and the allostatic interoceptive network in dementia
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceCardiovascular research
dspace.entity.typePublication
relation.isAuthorOfPublicationb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoveryb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c

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