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Allostatic load calculation in a Chilean older-adults cohort reveals the need for age-specific clinical thresholds

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dc.contributor.authorBuller, Ingrid
dc.contributor.authorMuniz, Graciela
dc.contributor.authorLillo, Patricia
dc.contributor.authorRiquelme, Patricio
dc.contributor.authorDemanet, Michele
dc.contributor.authorSaguez, Rodrigo
dc.contributor.authorDamm, Francisca
dc.contributor.authorSalech, Felipe
dc.contributor.authorGonzalez, Christian
dc.contributor.authorCourt, Felipe
dc.contributor.authorThumala, Daniela
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.date.accessioned2026-11-04T19:54:51Z
dc.date.available2026-11-04T19:54:51Z
dc.date.issued2025
dc.description.abstractOnly few studies of Allostatic Load (AL) have been conducted in Latin-American cohorts. Here, we replicated a recently proposed comprehensive algorithm (ALCS) to derive an AL index in a Chilean cohort of cognitive healthy adults. Using data from the GERO cohort (n = 166, age 76.92 ± 5.07 years) we generated an ALCS AL index through and compared for model fit with a purely sample distribution l algorithm (ALES). ALCS largely improved when some clinical values were corrected for ages ≥65, although failed to achieve sufficient goodness of fit. A final inclusion of an additional inflammatory biomarker resulted in further improvement of ALES, but not on ALCS. The ALES algorithm, which do not include clinical thresholds, achieved satisfactory fit after correcting for sample disparities between sexes. This suggests the need to consider the suitability of clinical thresholds developed in younger populations and the need to develop specific thresholds for assessing older adults.
dc.description.versionVersión Publicada
dc.identifier.citationBuller-Peralta, I., Muniz-Terrera, G., Lillo, P. et al. Allostatic load calculation in a Chilean older-adults cohort reveals the need for age-specific clinical thresholds. npj Dement. 1, 26 (2025). https://doi.org/10.1038/s44400-025-00032-0
dc.identifier.doihttps://doi.org/10.1038/s44400-025-00032-0
dc.identifier.urihttps://hdl.handle.net/11447/11323
dc.language.isoen
dc.subjectAllostatic Load
dc.subjectAllostatic Load comprehensive algorithm
dc.titleAllostatic load calculation in a Chilean older-adults cohort reveals the need for age-specific clinical thresholds
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourcenpj dementia
dspace.entity.typePublication
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoverye25c3d3e-63b5-4e04-951a-12a4989aa772

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