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Author Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

dc.contributor.authorMoguilner, Sebastian
dc.contributor.authorBaez, Sandra
dc.contributor.authorHernandez, Hernan
dc.contributor.authorMigeot, Joaquín
dc.contributor.authorLegaz, Agustina
dc.contributor.authorGonzalez, Raul
dc.contributor.authorFarina, Francesca
dc.contributor.authorPrado, Pavel
dc.contributor.authorCuadros, Jhosmary
dc.contributor.authorTagliazucchi, Enzo
dc.contributor.authorAltschuler, Florencia
dc.contributor.authorMaito, Marcelo
dc.contributor.authorGodoy, María
dc.contributor.authorCruzat, Josefina
dc.contributor.authorValdes, Pedro
dc.contributor.authorLopera, Francisco
dc.contributor.authorOchoa, John
dc.contributor.authorGonzalez, Alfredis
dc.contributor.authorBonilla, Jasmin
dc.contributor.authorGonzalez, Rodrigo
dc.contributor.authorAnghinah, Renato
dc.contributor.authord'Almeida, Luís
dc.contributor.authorFittipaldi, Sol
dc.contributor.authorMedel, Vicente
dc.contributor.authorOlivares, Daniela
dc.contributor.authorYener, Görsev
dc.contributor.authorEscudero, Javier
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorWhelan, Robert
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorYırıkoğulları, Harun
dc.contributor.authorSantamaria, Hernando
dc.contributor.authorFernández, Alberto
dc.contributor.authorHuepe, David
dc.contributor.authorDi Caterina, Gaetano
dc.contributor.authorSoto, Marcio
dc.contributor.authorBirba, Agustina
dc.contributor.authorSainz, Agustin
dc.contributor.authorCoronel, Carlos
dc.contributor.authorYigezu, Amanuel
dc.contributor.authorBehrens, Maria Isabel
dc.date.accessioned2024-12-17T20:06:55Z
dc.date.available2024-12-17T20:06:55Z
dc.date.issued2024
dc.descriptionHerrera, Eduar; Yerlikaya, Deniz; Hu, Kun; Parra, Mario; Reyes, Pablo; García, Adolfo; Custodio, Nilton; Cardona, Juan; Barttfeld, Pablo; Brusco, Ignacio; Bruno, Martín; Ana, Sosa; Pina, Stefanie; Takada; Leonel; Resende, Elisa; Possin, Katherine; de Oliveira, Maira; Lopez, Alejandro; Lawlor, Brian; Robertson, Ian; Kosik, Kenneth; Duran, Claudia; Valcour, Victor; Yokoyama, Jennifer; Miller, Bruce; Ibanez, Agustin.
dc.description.abstractLos relojes cerebrales capturan la diversidad y las disparidades en el envejecimiento y la demencia en poblaciones geográficamente diversas. Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations. Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex and neurodegeneration) on the brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American and Caribbean countries (LAC) and 8 non-LAC countries). Based on higher-order interactions, we developed a brain-age gap deep learning architecture for functional magnetic resonance imaging (2,953) and electroencephalography (2,353). The datasets comprised healthy controls and individuals with mild cognitive impairment, Alzheimer disease and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (functional magnetic resonance imaging: mean directional error = 5.60, root mean square error (r.m.s.e.) = 11.91; electroencephalography: mean directional error = 5.34, r.m.s.e. = 9.82) associated with frontoposterior networks compared with non-LAC models. Structural socioeconomic inequality, pollution and health disparities were influential predictors of increased brain-age gaps, especially in LAC (R² = 0.37, F² = 0.59, r.m.s.e. = 6.9). An ascending brain-age gap from healthy controls to mild cognitive impairment to Alzheimer disease was found. In LAC, we observed larger brain-age gaps in females in control and Alzheimer disease groups compared with the respective males. The results were not explained by variations in signal quality, demographics or acquisition methods. These findings provide a quantitative framework capturing the diversity of accelerated brain aging.
dc.description.versionVersión Publicada
dc.identifier.citationMoguilner S, Baez S, Hernandez H, Migeot J, Legaz A, Gonzalez-Gomez R, Farina FR, Prado P, Cuadros J, Tagliazucchi E, Altschuler F, Maito MA, Godoy ME, Cruzat J, Valdes-Sosa PA, Lopera F, Ochoa-Gómez JF, Hernandez AG, Bonilla-Santos J, Gonzalez-Montealegre RA, Anghinah R, d'Almeida Manfrinati LE, Fittipaldi S, Medel V, Olivares D, Yener GG, Escudero J, Babiloni C, Whelan R, Güntekin B, Yırıkoğulları H, Santamaria-Garcia H, Lucas AF, Huepe D, Di Caterina G, Soto-Añari M, Birba A, Sainz-Ballesteros A, Coronel-Oliveros C, Yigezu A, Herrera E, Abasolo D, Kilborn K, Rubido N, Clark RA, Herzog R, Yerlikaya D, Hu K, Parra MA, Reyes P, García AM, Matallana DL, Avila-Funes JA, Slachevsky A, Behrens MI, Custodio N, Cardona JF, Barttfeld P, Brusco IL, Bruno MA, Sosa Ortiz AL, Pina-Escudero SD, Takada LT, Resende E, Possin KL, de Oliveira MO, Lopez-Valdes A, Lawlor B, Robertson IH, Kosik KS, Duran-Aniotz C, Valcour V, Yokoyama JS, Miller B, Ibanez A. Author Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations. Nat Med. 2024 Dec;30(12):3779. doi: 10.1038/s41591-024-03294-y. Erratum for: Nat Med. 2024 Dec;30(12):3646-3657. doi: 10.1038/s41591-024-03209-x.
dc.identifier.doihttps://doi.org/10.1038/s41591-024-03294-y
dc.identifier.urihttps://hdl.handle.net/11447/9497
dc.language.isoen
dc.titleAuthor Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceNature Medicine
dspace.entity.typePublication
relation.isAuthorOfPublicationb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c
relation.isAuthorOfPublication.latestForDiscoveryb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c

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