Publication:
Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task

dc.contributor.authorGajardo-Vidal, Andrea
dc.contributor.authorMaxime Montembeault, Maxime
dc.contributor.authorLorca-Puls, Diego L.
dc.contributor.authorLicata, Abigail E.
dc.contributor.authorBogley, Rian
dc.contributor.authorErlhoff, Sabrina
dc.contributor.authorRatnasiri, Buddhika
dc.contributor.authorEzzes, Zoe
dc.contributor.authorBattistella, Giovanni
dc.contributor.authorTsoy, Elena
dc.contributor.authorWatson Pereira, Christa
dc.contributor.authorDeLeon, Jessica
dc.contributor.authorLead Tee , Boon
dc.contributor.authorHenry, Maya L.
dc.contributor.authorMiller, Zachary A.
dc.contributor.authorRankin, Katherine P.
dc.contributor.authorMandelli, Maria Luisa
dc.contributor.authorKatherine L. Possin, Katherine
dc.contributor.authorGorno-Tempini, Maria Luisa
dc.date.accessioned2025-01-13T16:31:47Z
dc.date.available2025-01-13T16:31:47Z
dc.date.issued2024
dc.description.abstractPrior research has revealed distinctive patterns of impaired language abilities across the three variants of Primary Progressive Aphasia (PPA): nonfluent/agrammatic (nfvPPA), logopenic (lvPPA) and semantic (svPPA). However, little is known about whether, and to what extent, non-verbal cognitive abilities, such as processing speed, are impacted in PPA patients. This is because neuropsychological tests typically contain linguistic stimuli and require spoken output, being therefore sensitive to verbal deficits in aphasic patients. The aim of this study is to investigate potential differences in processing speed between PPA patients and healthy controls, and among the three PPA variants, using a brief non-verbal tablet-based task (Match) modeled after the WAIS-III digit symbol coding test, and to determine its neural correlates. Here, we compared performance on the Match task between PPA patients (n = 61) and healthy controls (n = 59) and across the three PPA variants. We correlated performance on Match with voxelwise gray and white matter volumes. We found that lvPPA and nfvPPA patients performed significantly worse on Match than healthy controls and svPPA patients. Worse performance on Match across PPA patients was associated with reduced gray matter volume in specific parts of the left middle frontal gyrus, superior parietal lobule, and precuneus, and reduced white matter volume in the left parietal lobe. To conclude, our behavioral findings reveal that processing speed is differentially impacted across the three PPA variants and provide support for the potential clinical utility of a tabled-based task (Match) to assess non-verbal cognition. In addition, our neuroimaging findings confirm the importance of a set of fronto-parietal regions that previous research has associated with processing speed and executive control. Finally, our behavioral and neuroimaging findings combined indicate that differences in processing speed are largely explained by the unequal distribution of atrophy in these fronto-parietal regions across the three PPA variants.
dc.description.versionVersión publicada
dc.format.extent13 p.
dc.identifier.citationAndrea Gajardo-Vidal, Maxime Montembeault, Diego L. Lorca-Puls, Abigail E. Licata, Rian Bogley, Sabrina Erlhoff, Buddhika Ratnasiri, Zoe Ezzes, Giovanni Battistella, Elena Tsoy, Christa Watson Pereira, Jessica DeLeon, Boon Lead Tee, Maya L. Henry, Zachary A. Miller, Katherine P. Rankin, Maria Luisa Mandelli, Katherine L. Possin, Maria Luisa Gorno-Tempini, Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task, Cortex, Volume 171, 2024, Pages 165-177, ISSN 0010-9452, https://doi.org/10.1016/j.cortex.2023.10.011.
dc.identifier.doihttps://doi.org/10.1016/j.cortex.2023.10.011
dc.identifier.urihttps://hdl.handle.net/11447/9630
dc.language.isoen
dc.subjectDigital assessment
dc.subjectFronto-parietal regions
dc.subjectPrimary progressive aphasia
dc.subjectProcessing speed.
dc.titleAssessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceCortex
dspace.entity.typePublication
relation.isAuthorOfPublicationfa476211-172c-4c2e-88c2-87563070d587
relation.isAuthorOfPublication.latestForDiscoveryfa476211-172c-4c2e-88c2-87563070d587

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