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Kinin Receptors B1 and B2 Mediate Breast Cancer Cell Migrationand Invasion by Activating the FAK-Src Axis

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dc.contributor.authorGonzález, Felipe
dc.contributor.authorLobos, Lorena
dc.contributor.authorRiquelme, Alexander
dc.contributor.authorIbacache, Andrés
dc.contributor.authorMeza, Luis
dc.contributor.authorDroguett, Alexandra
dc.contributor.authorAlveal, Camila
dc.contributor.authorCarrillo, Bastián
dc.contributor.authorGutiérrez, Javiera
dc.contributor.authorEhrenfeld, Pamela
dc.contributor.authorCárdenas, Areli
dc.date.accessioned2025-08-18T20:33:28Z
dc.date.available2025-08-18T20:33:28Z
dc.date.issued2024
dc.description.abstractKinin receptors B1 and B2 are involved in migration and invasion in gastric, glioma, and cervical cancer cells, among others. However, the role of kinin receptors in breast cancer cells has been poorly studied. We aimed to reveal the impact of B1 and B2 receptors on migration and invasion in breast cancer cells and demonstrate their capacity to modulate in vivo tumor growth. MDA-MB-231, MCF-7, and T47D cells treated with Lys-des[Arg9]bradykinin (LDBK) or bradykinin (BK) were used to evaluate migration and invasion. Des-[Arg9]-Leu8-BK and HOE-140 were used as antagonists for the B1 and B2 receptors. MDA-MB-231 cells incubated or not with antagonists were subcutaneously inoculated in BALBc NOD/SCID mice to evaluate tumor growth. LDBK and BK treatment significantly increased migration and invasion in breast cancer cells, effects that were negated when antagonists were used. The use of antagonists in vivo inhibited tumor growth. Moreover, the migration and invasion induced by kinins in breast cancer cells were inhibited when focal adhesion kinase (FAK) and Src inhibitors were used. The novelty revealed in our work is that B1 and B2 receptors activated by LDBK and BK induce migration and invasion in breast cancer cells via a mechanism that involves the FAK-Src signaling pathway, and the antagonism of both receptors in vivo impairs breast tumor growth.
dc.description.versionVersión Publicada
dc.identifier.citationGonzález-Turén F, Lobos-González L, Riquelme-Herrera A, Ibacache A, Meza Ulloa L, Droguett A, Alveal C, Carrillo B, Gutiérrez J, Ehrenfeld P, Cárdenas-Oyarzo A. Kinin Receptors B1 and B2 Mediate Breast Cancer Cell Migration and Invasion by Activating the FAK-Src Axis. Int J Mol Sci. 2024 Oct 31;25(21):11709. doi: 10.3390/ijms252111709
dc.identifier.doihttps://doi.org/10.3390/ijms252111709
dc.identifier.urihttps://hdl.handle.net/11447/10171
dc.language.isoen
dc.titleKinin Receptors B1 and B2 Mediate Breast Cancer Cell Migrationand Invasion by Activating the FAK-Src Axis
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceInternational journal of molecular sciences
dspace.entity.typePublication

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