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Association of Dual-Phase Computed Tomography Angiography and CTPerfusion in Patients with Acute Ischemic Stroke Beyond the 6-Hour Window

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dc.contributor.authorGallardo, Andrés
dc.contributor.authorLavados, Pablo
dc.contributor.authorCox, Pablo
dc.contributor.authorDe la Barra, Camila
dc.contributor.authorCavada, Gabriel
dc.contributor.authorOlavarria, Verónica
dc.date.accessioned2023-08-02T16:18:15Z
dc.date.available2023-08-02T16:18:15Z
dc.date.issued2023
dc.description.abstractBackground: There is controversy regarding the need to use advanced imaging to select candidates for thrombectomy in late window acute ischemic stroke (AIS). Hypoattenuation on CT angiography source images (CTA-SI) in arterial phase has been shown to be more sensitive than Alberta Stroke Program Early CT score (ASPECTS) of brain parenchyma to determine tissue at risk of ischemia. Our hypothesis is that the addition of a second acquisition at 35-50 seconds could complement the assessment of hypoperfused tissue that fails to receive flow through pial vessels. Methods: Patients with large vessel occlusion and 6-16 hours from symptom onset, admitted between August 2019 and July 2022 were evaluated with dualphase CT angiography (CTA) and CT-perfusion. The association between automated CT-perfusion valuesand dual-phase CTA was assessed through a correlation coefficient. Results: Pearson's coefficient demonstrated a high correlation between ischemic core volume and delayed CTA-SI with an inverse association of -0.91 and between Tmax≥6 sec volume and arterial CTA-SI with a value of -0.83. Conclusion: CTA-derived source images (CTA-SI) in two phases may be useful in the selection of patients with AIS presenting beyond the 6-hour window.
dc.description.versionVersión Publicada
dc.identifier.citationVera, A. G., Barra, C. D. L., Cavada, G., Lavados, P., Cox Vial, P., & V Olavarria, V. (2023, July 11). Association of Dual-Phase Computed Tomography Angiography and CT-Perfusion in Patients with Acute Ischemic Stroke Beyond the 6-Hour Window. Progress in Neurobiology, 1–6. https://doi.org/10.31487/j.pneuro.2023.10.02
dc.identifier.doihttps://doi.org/10.31487/j.PNEURO.2023.10.02
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7822
dc.language.isoen
dc.subjectDual-phase computed tomography angiography
dc.subjectCT-Perfusion
dc.subjectLate window acute ischemic stroke
dc.titleAssociation of Dual-Phase Computed Tomography Angiography and CTPerfusion in Patients with Acute Ischemic Stroke Beyond the 6-Hour Window
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceProgress in Neurobiology
dspace.entity.typePublication

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