Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis

Miller, William; Nguyen, April; Singh, Kavindra; Rizvi, Samie; Khan, Ayesha; Erickson, Sam; Egge, Stephanie; Cruz, Melissa; Dinh, An; Diaz, Lorena; Thornton, Philip; Zhang, Rutan; Xu, Libin; Garsin, Danielle; Shamoo, Yousif; Arias, Cesar

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Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis

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Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis.pdf (1.17 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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item.page.doiurl

https://doi.org/10.1093/infdis/jiae173

URI

https://hdl.handle.net/11447/10984

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Acceso Abierto

Abstract

Enterococci have evolved resistance mechanisms to protect their cell envelopes against bacteriocins and host cationic antimicrobial peptides (CAMPs) produced in the gastrointestinal environment. Activ...

Citation

Miller WR, Nguyen A, Singh KV, Rizvi S, Khan A, Erickson SG, Egge SL, Cruz M, Dinh AQ, Diaz L, Thornton PC, Zhang R, Xu L, Garsin DA, Shamoo Y, Arias CA. Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis. J Infect Dis. 2025 Feb 20;231(2):307-317. doi: 10.1093/infdis/jiae173

Keywords

Enterococcus faecalis , antimicrobial peptides , cell envelope stress response , daptomycin , membrane lipids

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