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Functional Capacity in Activities of Daily Living in the Alzheimer’s Disease Continuum

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dc.contributor.authorHenriquez, Fernando
dc.contributor.authorDomínguez, Carmen
dc.contributor.authorGrandi, Fabrissio
dc.contributor.authorGonzalez, Cecilia
dc.contributor.authorRiquelme, Patricio
dc.contributor.authorLillo, Patricia
dc.contributor.authorMartínez, David
dc.contributor.authorThumala, Daniela
dc.contributor.authorHenriquez, Rodrigo
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.date.accessioned2025-08-25T17:44:53Z
dc.date.available2025-08-25T17:44:53Z
dc.date.issued2024
dc.description.abstractBackground The most common and prevalent dementia worldwide is Alzheimer’s disease (AD). AD is a continuum composed of Subjective Cognitive Impairment (SCD), Mild Cognitive Impairment (MCI), and Alzheimer’s Disease dementia (ADD) stage. One of the main clinical variables in patients with dementia is performance in functional capacity since its alterations are associated with poor prognosis and disease progression. Functional capacity is measured through activities of daily living (ADL), which are divided into three domains: i) Basic (BADL), ii) Instrumental (IADL), and iii) Advanced (AADL). The study aimed to characterize the performance of the different stages of the AD continuum in the ADL domains and their association with cognitive abilities. Method A cross-sectional study of subjects at different stages of the AD continuum was conducted: Healthy Controls (CTR) (n = 17), SCD (n = 77), MCI (n = 30), and ADD (n = 23), who were matched for age, sex, and education. ADLs were estimated using The Technology-Activities of Daily Living Questionnaire (T-ADLQ), which assesses the three domains and a total score. T-ADLQ performance was compared across groups and correlated with cognitive ability instruments (ACE-III and IFS). Result The results showed that patients with ADD performed worse on the BADL, IADL, and total ADLs compared to the other three groups. There were no significant differences between the CTR, SCD, and MCI on the BADL, IADL, and total ADLs. However, the AADL, in addition to differentiating the ADD patients from the other three groups, also showed differences between CTR and MCI subjects and between SCD and MCI subjects (Table 1 and Figure 1). The correlation study showed that AADL correlated significantly with global cognitive and executive function assessment (Figure 2). Conclusion AADL shows progressive functional impairment at different stages of the AD continuum, which is further associated with global cognitive and executive function performances. As one progresses to a more advanced stage of the disease continuum, the performance of ADLs, especially AADLs, worsens, which could indicate a marker of disease progression, allowing for better patient follow-up.
dc.description.versionVersión Aceptada
dc.identifier.citationHenriquez, F., Dominguez, C., Grandi, F., Campo, C. G., Contreras, P. R., Lillo, P., Martínez‐Pernía, D., Thumala, D., Henriquez, R., Aboitiz, F., & Chonchol, A. S. (2024). Functional capacity in activities of daily living in the Alzheimer’s disease continuum. Alzheimer´s & Dementia, 20(S3). https://doi.org/10.1002/alz.088521
dc.identifier.doihttps://doi.org/10.1002/alz.088521
dc.identifier.urihttps://hdl.handle.net/11447/10221
dc.language.isoen
dc.subjectCross-sectional study
dc.subjectAlzheimer's disease related dementia
dc.subjectClinical study and study designs
dc.subjectDementia
dc.subjectTranslational research and clinical interventions
dc.subjectMild cognitive impairment
dc.titleFunctional Capacity in Activities of Daily Living in the Alzheimer’s Disease Continuum
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceAlzheimer S & Dementia
dspace.entity.typePublication
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoverye25c3d3e-63b5-4e04-951a-12a4989aa772

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