Publication:
The Janus of a disease: Diabetes and metabolic dysfunction-associated fatty liver disease

Simple item page
dc.contributor.authorBarrera, Francisco
dc.contributor.authorUribe, Javier
dc.contributor.authorOlivares, Nixa
dc.contributor.authorHuerta, Paula
dc.contributor.authorCabrera, Daniel
dc.contributor.authorRomero-Gómez, Manuel
dc.date.accessioned2024-12-16T15:56:58Z
dc.date.available2024-12-16T15:56:58Z
dc.date.issued2024
dc.description.abstractMetabolic Dysfunction-Associated Fatty Liver Disease and Diabetes Mellitus are two prevalent metabolic disorders that often coexist and synergistically contribute to the progression of each other. Several pathophysiological pathways are involved in the association, including insulin resistance, inflammation, and lipotoxicity, providing a foundation for understanding the complex interrelationships between these conditions. The presence of MASLD has a significant impact on diabetes risk and the development of microvascular and macrovascular complications, and diabetes significantly contributes to an increased risk of liver fibrosis progression in MASLD and the development of hepatocellular carcinoma. Moreover, both pathologies have a synergistic effect on cardiovascular events and mortality. Therapeutic interventions targeting MASLD and diabetes are discussed, considering lifestyle modifications, pharmacological agents, and emerging treatment modalities. The review also addresses the challenges in managing these comorbidities, such as the need for personalized approaches and the potential impact on cardiovascular health. The insights gleaned from this analysis can inform clinicians, researchers, and policymakers in developing integrated strategies for preventing, diagnosing, and managing these metabolic disorders.
dc.description.versionVersión publicada
dc.format.extent10 p.
dc.identifier.citationBarrera F, Uribe J, Olvares N, Huerta P, Cabrera D, Romero-Gómez M. The Janus of a disease: Diabetes and metabolic dysfunction-associated fatty liver disease. Ann Hepatol. 2024 Jul-Aug;29(4):101501. doi: 10.1016/j.aohep.2024.101501
dc.identifier.doihttps://doi.org/10.1016/j.aohep.2024.101501
dc.identifier.urihttps://hdl.handle.net/11447/9479
dc.language.isoen
dc.subjectFatty liver
dc.subjectMetabolic associated fatty liver disease
dc.subjectMASLD
dc.subjectDiabetes
dc.subjectMetabolic syndrome
dc.subjectHepatic steatosis
dc.subjectInsulin resistance
dc.titleThe Janus of a disease: Diabetes and metabolic dysfunction-associated fatty liver disease
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceAnnals of Hepatology
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S1665268124002953-main.pdf
Size:
1.68 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services